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Amount of expense for award under share-based payment arrangement. Excludes amount capitalized.

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The weighted-average price as of the balance sheet date at which grantees can acquire the shares reserved for issuance on vested portions of options outstanding and currently exercisable under the stock option plan.

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Net number of share options (or share units) granted during the period.

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An excess of the fair value of the modified award over the fair value of the award immediately before the modification.

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Description of terms of award under share-based payment arrangement.

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Number of options vested.

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Stock Based Compensation - Additional Information (Detail) - USD ($) $ / shares in Units, $ in Thousands	1 Months Ended	3 Months Ended
	Jun. 30, 2017	Mar. 31, 2023	Mar. 31, 2022
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Stock-based compensation expense		$ 41,250	$ 29,198
Stock-based compensation expenses		$ 41,300	$ 29,200
Grants, Stock options		1,030,349	1,291,537
Chief Executive Officer
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Grants, Stock options	3,300,000
Minimum [Member]
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Compound annual growth rate		5.00%
Unvested Tranche Member
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Stock-based compensation expense		$ 8,400
Incremental compensation cost		$ 5,000
Vesting, Stock options		550,110
Average closing price		$ 128.65
Share-Based Compensation Arrangement by Share-Based Payment Award, Terms of Award		550,110 options relating to the Unvested Tranche met the conditions for vesting as the average closing price of the Company's common stock exceeded $128.65 during 20 consecutive trading days in March 2023 and the compound annual growth rate of the Company's common stock exceeded that of the Nasdaq Biotech Index by greater than 5%