Summary of Stock Awards Granted (Detail) - $ / shares		3 Months Ended
		Mar. 31, 2023	Mar. 31, 2022
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Grants, Stock options		1,030,349	1,291,537
Weighted Average Grant Date Fair Value, Stock options		$ 72.80	$ 46.99
Grants, Restricted stock units	[1]	1,075,911	712,435
Weighted Average Grant Date Fair Value, Restricted stock units	[1]	$ 154.91	$ 79.98
Restricted Stock Units [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Grants, Stock options		502,225	38,500

[1] *Included in restricted stock units (“RSUs”) for the three months ended March 31, 2023 and 2022 are 502,225 and 38,500 shares, respectively, with performance conditions which are related to regulatory approval of certain of the Company's product candidates. As of March 31, 2023, none of the performance conditions are probable of being achieved. If the performance milestones are achieved within the required time frame, the Company may recognize up to $78.3 million of stock-based compensation related to these grants. Stock options and the remaining RSUs granted during the periods presented in the table have only service-based criteria and vest over four years.