Condensed Consolidated Statements of Stockholders' Equity - USD ($) $ in Thousands	Total	Common Stock [Member]	Additional Paid-In Capital [Member]	Accumulated Other Comprehensive (Loss) Income [Member]	Accumulated Deficit [Member]
Balance at Dec. 31, 2021	$ 928,009	$ 9	$ 4,134,768	$ (20)	$ (3,206,748)
Balance (in shares) at Dec. 31, 2021		87,127,000
Exercise of options for common stock	997		997
Exercise of options for common stock, shares		18,000
Vest of restricted stock units/awards		289,000
Partial settlement of capped call share options for 2024 Notes	0
Issuance of common stock under employee stock purchase plan	3,993		3,993
Issuance of common stock under employee stock purchase plan, shares		62,000
Stock-based compensation	29,198		29,198
Unrealized gains from available-for-sale securities, net of tax	(286)			(286)
Net loss	(105,025)				(105,025)
Balance at Mar. 31, 2022	856,886	$ 9	4,168,956	(306)	(3,311,773)
Balance (in shares) at Mar. 31, 2022		87,496,000
Balance at Dec. 31, 2022	384,950	$ 9	4,296,841	(1,664)	(3,910,236)
Balance (in shares) at Dec. 31, 2022		87,950,000
Exercise of options for common stock	22,808		22,808
Exercise of options for common stock, shares		267,000
Vest of restricted stock units/awards		390,000
Issuance of common stock for exchange of 2024 Notes	693,377		693,377
Issuance of common stock for exchange of 2024 Notes, shares		4,456,000
Partial settlement of capped call share options for 2024 Notes	80,645		80,645
Issuance of common stock under employee stock purchase plan	5,229		5,229
Issuance of common stock under employee stock purchase plan, shares		77,000
Stock-based compensation	41,250		41,250
Unrealized gains from available-for-sale securities, net of tax	(1,245)			(1,245)
Net loss	(516,755)				(516,755)
Balance at Mar. 31, 2023	$ 712,749	$ 9	$ 5,140,150	$ (419)	$ (4,426,991)
Balance (in shares) at Mar. 31, 2023		93,140,000