Summary of Other (Loss) Income, Net (Detail) - USD ($) $ in Thousands		12 Months Ended
		Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Investment Income, Nonoperating [Abstract]
Interest expense		$ (53,248)	$ (63,525)	$ (59,947)
Interest income		16,488	354	2,970
Amortization of investment discount		11,235	157	4,489
Impairment of equity investment		(2,575)	(4,488)	0
Other (expense) income		6,921	(936)	517
Other expense, net		(35,021)	(68,438)	(51,971)
Loss on debt extinguishment		(125,441)	0	0
Gain (loss) on contingent consideration, net*	[1]	6,700	7,200	(45,000)
Gain from sale of Priority Review Voucher		0	102,000	108,069
Total other (loss) income, net		$ (153,762)	$ 40,762	$ 11,098

[1] * The gain (loss) on contingent consideration, net is related to the fair value adjustment of the regulatory-related contingent payments that are accounted for as derivatives. Please see Note 5. Fair Value Measurements for further details.