Summary of Restricted Stock Unit Activity (Detail) - Restricted Stock Units (RSUs) [Member]	12 Months Ended
	Dec. 31, 2022 $ / shares shares
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Shares, Grants outstanding at beginning of the period | shares	1,320,206
Shares, Granted | shares	1,044,826	[1]
Shares, Vested | shares	(389,761)
Shares, Forfeited | shares	(145,639)
Shares, Grants outstanding at end of the period | shares	1,829,632
Weighted Average Grant Date Fair Value per Share, Grants outstanding at beginning of the period | $ / shares	$ 98.69
Weighted Average Grant Date Fair Value per Share, Granted | $ / shares	85.39	[1]
Weighted Average Grant Date Fair Value per Share, Vested | $ / shares	103.05
Weighted Average Grant Date Fair Value per Share, Forfeited | $ / shares	93.36
Weighted Average Grant Date Fair Value per Share, Grants outstanding at end of the period | $ / shares	$ 90.59

[1] Included in this amount are 38,500 RSUs with performance conditions relating to regulatory approval of certain of the Company's product candidates. As of December 31, 2022, none of the performance conditions were probable of being achieved. Accordingly, no stock-based compensation relating to these grants has been recognized. If the performance milestones are achieved within the required time frame, the Company may recognize up to $3.1 million of stock-based compensation related to these grants, which represents the aggregate grant date fair value of these awards. All other stock options and the remaining RSUs granted during the periods presented in the tables above have only service-based vesting conditions and the majority vest over four years.