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Stock Based Compensation - Additional Information (Detail) - USD ($)
$ / shares in Units, $ in Thousands
1 Months Ended 12 Months Ended
Jun. 30, 2017
Dec. 31, 2023
Dec. 31, 2022
Dec. 31, 2021
Dec. 31, 2020
Aug. 31, 2022
Jun. 30, 2020
Jun. 30, 2019
Jun. 30, 2018
Jun. 30, 2016
Sep. 30, 2014
Jun. 30, 2013
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                        
Term of award     10 years                  
Share based compensation granted under plan vest period     4 years                  
Weighted-average grant date fair value per share of stock-based awards, granted to employees     $ 48.82 $ 48.16 $ 61.38              
Stock-based compensation Grants     $ 3,100                  
Average closing price     $ 70.27                  
Fair value of options granted     48.82 $ 48.16 $ 61.38              
Granted     $ 84.70                  
Stock-based compensation expense     $ 233,018 $ 113,943 $ 108,070              
Unrecognized stock based compensation expense     $ 206,600                  
Weighted average period expected to recognize unrecognized stock base compensation expense     3 years                  
Options with Service conditions [Member]                        
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                        
Unrecognized stock based compensation expense     $ 98,900                  
Awards with Service and Market Conditions [Member]                        
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                        
Unrecognized stock based compensation expense     13,400                  
Stock Units with Service Conditions [Member]                        
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                        
Unrecognized stock based compensation expense     $ 94,300                  
Minimum [Member]                        
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                        
Compound annual growth rate     5.00%                  
Stock Options [Member]                        
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                        
Stock-based compensation expense     $ 174,868 $ 68,995 $ 68,832              
Restricted Stock Units (RSUs) [Member]                        
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                        
Share based compensation granted under plan vest period     4 years                  
Stock options granted     38,500                  
Grants, Restricted stock units and awards [1]     1,044,826                  
Restricted stock units and awards with performance conditions remaining to be vested     1,829,632 1,320,206                
CEO [Member]                        
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                        
Stock options granted 3,300,000                      
2013 Employee Stock Purchase Plan [Member]                        
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                        
Number of shares approved under the plan               500,000   300,000   300,000
Common stock remain available for future grant     200,000                  
Term of award     24 months                  
Percentage of closing price of common stock     85.00%                  
2013 Employee Stock Purchase Plan [Member] | Maximum [Member]                        
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                        
Share-based compensation award, expiration date     Aug. 31, 2024                  
2013 Employee Stock Purchase Plan [Member] | Minimum [Member]                        
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                        
Share-based compensation award, expiration date     Feb. 29, 2024                  
2014 Employment Commencement Incentive Plan (2014 Plan) [Member]                        
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                        
Number of shares approved under the plan                     600,000  
Common stock remain available for future grant     800,000                  
Common stock increase in available for future grant shares     7,000,000.0                  
2018 Equity Incentive Plan [Member]                        
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                        
Number of shares approved under the plan           2,500,000 3,800,000   2,900,000      
Common stock remain available for future grant     4,900,000                  
Share based compensation award tranche one [Member]                        
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                        
Share-Based Compensation Arrangement by Share-Based Payment Award, Terms of Award     550,110 options relating to the Unvested Tranche met the conditions for vesting in that the average closing price of the Company's common stock exceeded $105.74 during 20 consecutive trading days in August 2022 and the compound annual growth rate of the Company's common stock exceeded that of the Nasdaq Biotech Index by greater than 5%                  
Vesting, Stock options     550,110                  
Average closing price     $ 105.74                  
Stock-based compensation expense   $ 13,400 $ 109,900                  
Share based compensation award tranche one [Member] | CEO [Member]                        
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                        
Incremental compensation cost     $ 123,300                  
[1] Included in this amount are 38,500 RSUs with performance conditions relating to regulatory approval of certain of the Company's product candidates. As of December 31, 2022, none of the performance conditions were probable of being achieved. Accordingly, no stock-based compensation relating to these grants has been recognized. If the performance milestones are achieved within the required time frame, the Company may recognize up to $3.1 million of stock-based compensation related to these grants, which represents the aggregate grant date fair value of these awards. All other stock options and the remaining RSUs granted during the periods presented in the tables above have only service-based vesting conditions and the majority vest over four years.