INCOME TAXES (Tables)

12 Months Ended

Dec. 31, 2022

Income Tax Disclosure [Abstract]

Summary of Loss before Provision (Benefit) for Income Taxes by Jurisdiction

The following table summarizes the loss before the provision (benefit) for income taxes by jurisdiction for the periods indicated:

	For the Year Ended December 31,
	2022			2021			2020
	(in thousands)
Domestic	$	(251,384	)	$	(47,633	)	$	(204,956	)
Foreign		(438,579	)		(371,315	)		(348,109	)
Total	$	(689,963	)	$	(418,948	)	$	(553,065	)

Summary of Provision (Benefit) for Income Taxes

The following table summarizes provision (benefit) for income taxes in the accompanying consolidated financial statements for the periods indicated:

	For the Year Ended December 31,
	2022			2021			2020
	(in thousands)
Current provision:
Federal	$	—		$	—		$	4
State		13,193			(40	)		624
Foreign		944			181			680
Total current provision		14,137			141			1,308
Deferred benefit:
Federal		—			—			—
State		—			—			—
Foreign		(612	)		(309	)		(245	)
Total deferred benefit		(612	)		(309	)		(245	)
Total income tax expense (benefit)	$	13,525		$	(168	)	$	1,063

Reconciliation Between Effective Tax Rate and Statutory Income Tax Rate

The following table summarizes the reconciliation between the Company’s effective tax rate and the statutory income tax rate for each of the periods indicated:

	For the Year Ended December 31,
	2022				2021				2020
Federal income tax rate		21.0		%		21.0		%		21.0		%
State taxes		4.1				0.4				0.6
Research and development and other tax    credits		6.9				10.0				10.1
Valuation allowance		(14.7	)			(9.8	)			(21.3	)
Permanent differences		(3.3	)			(0.3	)			(1.6	)
Stock-based compensation		(1.2	)			(3.0	)			3.5
Foreign rate differential		(13.2	)			(18.4	)			(12.9	)
Other		(1.6	)			0.1				0.4
Effective tax rate		(2.0	)	%		(0.0	)	%		(0.2	)	%

Analysis of Deferred Tax Assets and Liabilities

The following table summarizes the analysis of the deferred tax assets and liabilities for each of the periods indicated:

	As of December 31,
	2022			2021
	(in thousands)
Deferred tax assets:
Net operating loss carryforwards	$	241,826		$	330,392
Difference in depreciation and amortization		39,725			31,563
Research and development tax credits		261,067			201,512
Stock-based compensation		80,193			38,132
Lease liabilities		11,782			10,890
Capitalized inventory		33,366			24,172
Debt discount		35,975			5,875
Capitalized research and development costs		74,886			—
Other		44,022			38,315
Total deferred tax assets		822,842			680,851
Deferred tax liabilities:
Right of use asset		(9,174	)		(7,405	)
Debt discount		—			—
Total deferred tax liabilities		(9,174	)		(7,405	)
Valuation allowance		(811,908	)		(672,319	)
Net deferred tax assets	$	1,760		$	1,127

Reconciliation of Beginning and Ending Amount of Unrecognized Tax Benefits

The follow table summarizes the reconciliation of the beginning and ending amount of total unrecognized tax benefits for each of the periods indicated:

	For the Year Ended December 31,
	2022			2021			2020
	(in thousands)
Balance at beginning of the period	$	53,815		$	48,475		$	41,753
Increase related to current year tax positions		8,079			5,503			6,722
Increase related to prior year tax positions		—			—			—
Decrease related to prior year tax positions		(190	)		(163	)		—
Balance at end of the period	$	61,704		$	53,815		$	48,475