Consolidated Balance Sheets - USD ($) $ in Thousands	Dec. 31, 2022	Dec. 31, 2021
Current assets:
Cash and cash equivalents	$ 966,777	$ 2,115,869
Short-term investments	1,022,597	0
Accounts receivable	214,628	152,990
Inventory	203,968	186,212
Other current assets	149,891	149,028
Total current assets	2,557,861	2,604,099
Property and equipment, net	180,037	191,156
Intangible assets, net	7,578	14,239
Right of use assets	64,954	45,531
Other non-current assets	317,936	292,949
Total assets	3,128,366	3,147,974
Current liabilities:
Accounts payable	95,875	76,741
Accrued expenses	418,996	271,697
Deferred revenue, current portion	89,244	89,244
Other current liabilities	15,489	15,051
Total current liabilities	619,604	452,733
Long-term debt	1,544,292	1,096,876
Lease liabilities, net of current portion	57,578	41,512
Deferred revenue, net of current portion	485,000	574,244
Contingent consideration	36,900	43,600
Other non-current liabilities	42	11,000
Total liabilities	2,743,416	2,219,965
Commitments and contingencies (Note 21)
Stockholders’ equity:
Preferred stock, $0.0001 par value, 3,333,333 shares authorized; none issued and outstanding	0	0
Common stock, $0.0001 par value, 198,000,000 shares authorized; 87,950,117 and 87,126,974 issued and outstanding at December 31, 2022 and 2021, respectively	9	9
Additional paid-in capital	4,296,841	4,134,768
Accumulated other comprehensive loss, net of tax	(1,664)	(20)
Accumulated deficit	(3,910,236)	(3,206,748)
Total stockholders’ equity	384,950	928,009
Total liabilities and stockholders’ equity	$ 3,128,366	$ 3,147,974