PROPERTY AND EQUIPMENT, NET

12 Months Ended

Dec. 31, 2022

Property, Plant and Equipment [Abstract]

PROPERTY AND EQUIPMENT, NET

10. PROPERTY AND EQUIPMENT, NET

Property and equipment are recorded at historical cost, net of accumulated depreciation. The following table summarizes components of property and equipment, net, for each of the periods indicated:

	As of December 31,
	2022			2021
	(in thousands)
Leasehold improvements	$	97,328		$	103,370
Lab and manufacturing equipment		91,806			64,613
Building and improvements		47,942			47,605
Software and computer equipment		47,573			42,506
Furniture and fixtures		9,313			9,242
Land		5,183			5,183
Land improvements		4,988			4,921
Office equipment		1,193			1,189
Construction in progress		23,587			25,159
Property and equipment, gross		328,913			303,788
Less: accumulated depreciation		(148,876	)		(112,632	)
Property and equipment, net	$	180,037		$	191,156

For the years ended December 31, 2022, 2021 and 2020, depreciation expense totaled $40.0 million, $36.6 million and $25.2 million, respectively.