8-K

UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

Date of Report (Date of earliest event reported): January 09, 2023

Sarepta Therapeutics, Inc.

(Exact name of Registrant as Specified in Its Charter)

Delaware	001-14895	93-0797222
(State or Other Jurisdiction of Incorporation)	(Commission File Number)	(IRS Employer Identification No.)
215 First Street
Cambridge, Massachusetts		02142
(Address of Principal Executive Offices)		(Zip Code)

Registrant’s Telephone Number, Including Area Code: (617) 274-4000

(Former Name or Former Address, if Changed Since Last Report)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

☐Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

☐Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

☐Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

☐Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Securities registered pursuant to Section 12(b) of the Act:

Title of each class	Trading Symbol(s)	Name of each exchange on which registered
Common Stock, $0.0001 par value per share	SRPT	NASDAQ Global Select Market

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§ 230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§ 240.12b-2 of this chapter).

Emerging growth company ☐

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

Item 2.02 Results of Operations and Financial Condition.

On January 9, 2023, Douglas S. Ingram, President and Chief Executive Officer of Sarepta Therapeutics, Inc. (the “Company”) disclosed certain preliminary financial information for the year ended December 31, 2022 during the Company’s presentation at the 41st Annual J.P. Morgan Healthcare Conference (the “Conference”) and in discussions with third parties at the Conference. Specifically, the Company disclosed its (unaudited) cash position of approximately $2.0 billion as of December 31, 2022 and that the Company expects total net product revenue (unaudited) for the fourth quarter ended December 31, 2022 to be approximately $235.5 million, and expects total net product revenue (unaudited) for the year ended December 31, 2022 to be approximately $843.3 million, each from sales of EXONDYS 51® (eteplirsen) Injection, VYONDYS 53® (golodirsen) Injection and AMONDYS 45® (casimersen) Injection.

The information in this Item 2.02 is unaudited and preliminary and does not present all information necessary for an understanding of the Company’s financial condition as of December 31, 2022 and its results of operations for the three months and year ended December 31, 2022. The audit of the Company’s financial statements for the year ended December 31, 2022 is ongoing and could result in changes to the information in this Item 2.02.

Item 7.01 Regulation FD Disclosure.

The disclosure in Item 2.02 above is hereby incorporated by reference into this Item 7.01. On January 9, 2023, the Company issued a press release disclosing such information.

Copies of the press release and the slides presented by Mr. Ingram at the Conference on January 9, 2023 are furnished with this report as Exhibit 99.1 and Exhibit 99.2, respectively.

The information in this report, including Exhibit 99.1 and Exhibit 99.2 attached hereto, is furnished pursuant to Items 2.02 and 7.01 and shall not be deemed “filed” for the purposes of Section 18 of the Securities and Exchange Act of 1934, as amended (the “Exchange Act”), or otherwise subject to the liabilities of that section. It may only be incorporated by reference in another filing under the Exchange Act or the Securities Act of 1933, as amended, if such subsequent filing specifically references the information furnished pursuant to Items 2.02 and 7.01 of this report.

Forward-Looking Statements

This Current Report contains forward looking statements. Any statements contained in this Current Report that are not statements of historical fact may be deemed to be forward-looking statements. Words such as “believes,” “anticipates,” “plans,” “expects,” “will,” “may,” “intends,” “prepares,” “looks,” “potential,” “possible” and similar expressions are intended to identify forward-looking statements. These forward-looking statements include statements relating to the Company's expected financial results.

These forward-looking statements involve risks and uncertainties, many of which are beyond the Company's control. Actual results could materially differ from those stated or implied by these forward-looking statements as a result of such risks and uncertainties. Known risk factors include the following: the estimates and judgments the Company makes, or the assumptions on which it relies, in preparing its consolidated financial statements could prove inaccurate; the Company's revenues and operating results could fluctuate significantly, which may adversely affect the Company's stock price; and those risks identified under the heading “Risk Factors” in the Company's Quarterly Report on Form 10-Q for the quarter ended September 30, 2022 as well as other SEC filings made by the Company which you are encouraged to review.

Item 9.01 Financial Statements and Exhibits.

(d) Exhibits

Exhibit Number	Description
99.1	Press Release dated January 9, 2023
99.2	Sarepta Therapeutics, Inc. Presentation at the 41st Annual J.P. Morgan Healthcare Conference, dated January 9, 2023
104	The cover page from this Current Report on Form 8-K of Sarepta Therapeutics, Inc., formatted in Inline XBRL and included as Exhibit 101

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

			Sarepta Therapeutics, Inc.
Date:	January 9, 2023	By:	/s/ Douglas S. Ingram
			Douglas S. Ingram President and Chief Executive Officer

EX-99.1

Exhibit 99.1

Sarepta Therapeutics Reports Preliminary* Fourth Quarter and Full-Year 2022 Net Product Revenues

–The Company expects to exceed 2022 full-year guidance for net product revenues

–Preliminary net product revenues for the fourth quarter and full-year 2022 are expected to total $235.5 million and $843.3 million, respectively

–Preliminary year-end 2022 cash balance of approximately $2.0 billion

CAMBRIDGE, Mass., Jan. 9, 2023 (GLOBE NEWSWIRE) -- Sarepta Therapeutics, Inc. (NASDAQ:SRPT), the leader in precision genetic medicine for rare diseases, today reported preliminary* fourth quarter and full-year 2022 net product revenues as part of their presentation today at the 41st Annual J.P. Morgan Healthcare Conference.

Financial Update* (preliminary and unaudited):

•Fourth quarter 2022 net product revenues are expected to be approximately $235.5 million, a 32% increase over the same period in 2021. Our net product revenues do not include collaboration revenues.

•Net product revenues for the full-year 2022 are expected to be $843.3 million, a 38% increase over the same period of 2021, which is also expected to exceed Sarepta’s net product revenue guidance of $825-840 million. Our expected net product revenues do not include collaboration revenues.

•As of December 31, 2022, the Company had preliminary cash, cash equivalents, restricted cash and investments of approximately $2.0 billion, as compared to approximately $2.1 billion as of December 31, 2021.

“We are pleased to have closed out 2022 on an extremely strong note with continued execution across our three RNA-based PMO therapies, delivering net product revenue that is expected to exceed our upwardly revised guidance range. These preliminary results reflect the mission-driven dedication and expertise of our teams to serve the nearly 30% of Duchenne patients who are amenable to one of our approved therapies,” said Doug Ingram, president and chief executive officer, Sarepta Therapeutics.

*These preliminary selected financial results are unaudited and subject to adjustment. Sarepta will report its final and complete fourth quarter and full-year 2022 financial results in late February 2023. The Company has not completed its financial closing procedures for the quarter or year ended December 31, 2022 and its actual results could be materially different from these preliminary financial results.

About Sarepta Therapeutics

Sarepta is on an urgent mission: engineer precision genetic medicine for rare diseases that devastate lives and cut futures short. We hold leadership positions in Duchenne muscular dystrophy (DMD) and

limb-girdle muscular dystrophies (LGMDs), and we currently have more than 40 programs in various stages of development. Our vast pipeline is driven by our multi-platform Precision Genetic Medicine Engine in gene therapy, RNA and gene editing. For more information, please visit www.sarepta.comor follow us on Twitter, LinkedIn, Instagram and Facebook.

Internet Posting of Information

We routinely post information that may be important to investors in the 'For Investors' section of our website at www.sarepta.com. We encourage investors and potential investors to consult our website regularly for important information about us.

Forward-Looking Statements

In order to provide Sarepta’s investors with an understanding of its current results and future prospects, this press release contains statements that are forward-looking. Any statements contained in this press release that are not statements of historical fact may be deemed to be forward-looking statements. Words such as “believes,” “anticipates,” “plans,” “expects,” “will,” “may,” “intends,” “prepares,” “looks,” “potential,” “possible” and similar expressions are intended to identify forward-looking statements. These forward-looking statements include statements relating to our expected financial results.

These forward-looking statements involve risks and uncertainties, many of which are beyond Sarepta’s control. Actual results could materially differ from those stated or implied by these forward-looking statements as a result of such risks and uncertainties. Known risk factors include the following: the estimates and judgments we make, or the assumptions on which we rely, in preparing our consolidated financial statements could prove inaccurate; our revenues and operating results could fluctuate significantly, which may adversely affect our stock price; and those risks identified under the heading “Risk Factors” in our Quarterly Report on Form 10-Q for the quarter ended September 30, 2022 as well as other SEC filings made by the Company which you are encouraged to review.

Source: Sarepta Therapeutics, Inc.

Investor Contact:

Ian Estepan, 617-274-4052

iestepan@sarepta.com

Media Contact:

Tracy Sorrentino, 617-301-8566

tsorrentino@sarepta.com

EX-99.2

Sarepta Therapeutics, Inc. (NASDAQ:SRPT) JPMorgan Healthcare Conference San Francisco, California January 9, 2023 Doug Ingram President and CEO Exhibit 99.2

Forward-looking statements This presentation contains "forward-looking statements." Any statements that are not statements of historical fact may be deemed to be forward-looking statements. Words such as “believe,” “anticipate,” “plan,” “expect,” “will,” “may,” “intend,” “prepare,” “look,” “potential,” “possible” and similar expressions are intended to identify forward-looking statements. These forward-looking statements include statements relating to future operations, financial performance and projections; our current guidance for 2023 for our three currently approved therapies of more than $925 million in net revenue; our opportunities in the rare disease space; potential solutions and market opportunities with our RNA technologies, gene therapy and gene editing; the potential benefits of our technologies and scientific approaches; the potential benefits of PMO and PPMO; the potentially transformative benefits of SRP-9001, including SRP-9001’s potential to transform the trajectory of Duchenne, the potential restoration of DAPC, reduced CK and improved histopathology, and the potential of improved benefit received from SRP-9001 over time; our belief that the 9001-dytsrophin protein is reasonably likely to predict clinical benefit; our belief that our internal gene therapy capabilities complimented by partnerships will meet demand to launch SRP-9001, if approved, and drive competitive costs with continued improvements to drive upside; our belief that the transformative one-time therapy, SRP-9001, will cost the system less than the value it will provide to the Duchenne community; the potential of gene therapy’s applicability across disease; the potential of our collaborations and partnerships; and expected milestones and plans, including our belief that we may receive an advisory Committee meeting for SRP-9001, launching SRP-9001 in the middle of 2023, if SRP-9001 is approved, having a readout of our confirmatory trial for SRP-9001 at the end of the year, expanding the available label of SRP-9001 after additional studies by 2024, publishing our perspective on the holistic approach to value innovative one-time therapies like SRP-9001, our expectation that we will have approximately 30 clinical trials ongoing by the end of 2023, continuing to build our pipeline, and our expectations related to our future financial performance, including if SRP-9001 is approved, our forecasted peek year SRP-9001 net product revenue will be nearly $4 billion, tracking to nearly $5 billion in total net product venue, by 2026, if we meet our strategic plan goals, including if SRP-9001 is approved, we will be cash positive and profitable by next year, and updating our guidance to include SRP-9001 net sales for 2023, if SRP-9001 is approved. These forward‐looking statements involve risks and uncertainties, many of which are beyond our control and are based on our current beliefs, expectations and assumptions regarding our business. Actual results and financial condition could materially differ from those stated or implied by these forward‐looking statements as a result of such risks and uncertainties, and such risks and uncertainties could materially and adversely affect our business, results of operations and trading price. Potential known risk factors include, among others, the following: we may not be able to comply with all FDA post-approval commitments and requirements with respect to EXONDYS 51, VYONDY 53 and AMONDYS 45 in a timely manner or at all; our data for our different programs, including PPMO and gene therapy-based product candidates, may not be sufficient for obtaining regulatory approval; our product candidates, including those with strategic partners, may not result in viable treatments suitable for commercialization due to a variety of reasons, including the results of future research may not be consistent with past positive results or may fail to meet regulatory approval requirements for the safety and efficacy of product candidates; success in preclinical testing and early clinical trials, especially if based on a small patient sample, does not ensure that later clinical trials will be successful; the impact of the COVID-19 pandemic; the expected benefits and opportunities related to our agreements with our strategic partners may not be realized or may take longer to realize than expected due to a variety of reasons, including any inability of the parties to perform their commitments and obligations under the agreements, challenges and uncertainties inherent in product research and development and manufacturing limitations; if the actual number of patients living with Duchenne and LGMD is smaller than estimated, our revenue and ability to achieve profitability may be adversely affected; our dependence on our manufacturers to fulfill our needs for our clinical trials and commercial supply, including any failure on our part to accurately anticipate product demand and timely secure manufacturing capacity to meet product demand, may impair the availability of products to successfully support various programs, including research and development and the potential commercialization of our gene therapy product candidates; we may not be able to successfully scale up manufacturing of our product candidates in sufficient quality and quantity or within sufficient timelines; current reimbursement models may not accommodate the unique factors of our gene therapy product candidates; we may not be able to execute on our business plans and goals, including meeting our expected or planned regulatory milestones and timelines, clinical development plans, and bringing our product candidates to market, for various reasons including possible limitations of our financial and other resources, manufacturing limitations that may not be anticipated or resolved for in a timely manner, regulatory, court or agency decisions, such as decisions by the United States Patent and Trademark Office; and those risks identified under the heading “Risk Factors” in Sarepta’s most recent Annual Report on Form 10-K and most recent Quarterly Report on Form 10‐Q filed with the Securities and Exchange Commission (SEC) and in its other SEC filings. For a detailed description of risks and uncertainties Sarepta faces, you are encouraged to review Sarepta's filings with the SEC. We caution investors not to place considerable reliance on the forward‐looking statements contained in this presentation. The forward‐looking statements in this presentation are made as of the date of this presentation only and, other than as required under applicable law, Sarepta does not undertake any obligation to publicly update its forward‐looking statements.

BENJAMIN Living with Duchennemuscular dystrophy A Bellwether Moment…

SRP-9001 Poised to transform the trajectory of Duchenne muscular dystrophy THE OPPORTUNITY

1. Birnkrant et al. Lancet Neurol. 2018 Mar;17(3):251-267; 2. Verma et al. Clin Pediatr (Phila). 2010 Nov;49(11):1011-7; 3. Aartsma-Rus et al. Hum Mutat. 2009 Mar;30(3):293-9; 4. Duchenne UK, Stages of Duchenne https://www.duchenneuk.org/Pages/FAQs/Category/stages-of-duchenne (last accessed August 2018); 5. Janssen et al. J Neurol. 2014 Jul;261(7):1269-88; 6. Rall and Grimm. Acta Myol. 2012 Oct;31(2):117-20; 7. Koeks et al. J Neuromuscul Dis. 2017;4(4):293-306; 8. Ryder et al. Orphanet J Rare Dis. 2017 Apr 26;12(1):79; 9. Birnkrant et al. Lancet Neurol. 2018 Apr;17(4):347-361; 10. Archer et al. J Spine Surg. 2016 Sep;2(3):185-19; 11. LoMauro et al. Ther Clin Risk Manag. 2015 28;11:1475-88. Duchenne is progressive and causes irreversible muscle damage and loss of function Lack of dystrophin causes muscle damage1,2,3 BIRTH 2-5 years 5-10 years 7-15 years 10-14 years 8-30 years 10-30 years 15-30 years 20-30 years Delayed milestones, Gower’s sign and toe-walking1,2,4 Difficulty walking, balancing and climbing stairs, change in posture, use of walking aids required1,2,4 Pain and limitations in upper limbs2,4,5 LOA and wheelchair use at around 12 years,2,4,6,7,8 onset of scoliosis2,9,10 Loss of upper limb function1,2,5 Pulmonary decline1 Cardiomyopathy and heart failure4,9 Night-time ventilation progressing to 24h ventilation6,7,8,9,11 PROGRESSIVE & IRREVERSIBLE MUSCLE DAMAGE LEADING TO PREMATURE DEATH 0 5 10 15 20 25 30 YEARS Gower’s sign Toe-walking

Restoring the dystrophin-associated protein complex (DAPC) restores function

Becker muscular dystrophy (BMD) shortened dystrophin protein retains critical elements of dystrophin3-7 NORMAL MUSCLE3-7 61 YO AMBULATORY PATIENT8-9 1. Naso MF, et al. BioDrugs. 2017;31(4):317-334. 2. Chamberlain K, et al. Hum Gene Ther Methods. 2016;27(1):1-12. 3. Gao Q, et al. Compr Physiol. 2015;5(3):1223. 4. Harper SQ, et al. Nature Med. 2002;8(3):253. 5. Nelson DM, et al. Human Mol Genet. 2018 27(12):2090. 6. Fairclough RJ, et al. Nat Rev Genet. 2013;14:373-378. 7. Aartsma-Rus A, et al. Muscle Nerve. 2006;34(2):134-144. 8. England SB, et al. Nature. 1990;343(6254):180-182. 9. Wells DJ, et al. Hum Mol Genet. 1995;4(8):1245-1250. BMD patient – Produces a functioning shortened version of the protein of interest1,2

BMD shortened dystrophin protein retains critical elements of dystrophin3-7 SAREPTA SRP-9001 DYSTROPHIN3-7 61 YO AMBULATORY PATIENT8-9 1. Naso MF, et al. BioDrugs. 2017;31(4):317-334. 2. Chamberlain K, et al. Hum Gene Ther Methods. 2016;27(1):1-12. 3. Gao Q, et al. Compr Physiol. 2015;5(3):1223. 4. Harper SQ, et al. Nature Med. 2002;8(3):253. 5. Nelson DM, et al. Human Mol Genet. 2018 27(12):2090. 6. Fairclough RJ, et al. Nat Rev Genet. 2013;14:373-378. 7. Aartsma-Rus A, et al. Muscle Nerve. 2006;34(2):134-144. 8. England SB, et al. Nature. 1990;343(6254):180-182. 9. Wells DJ, et al. Hum Mol Genet. 1995;4(8):1245-1250. Transgene – Produces a functioning version of the protein of interest1,2

SRP-9001 has been rationally designed to maximize expression in tissues most affected by Duchenne1-6 AAVrh74 Viral Vector1-2 MHCK7 Promoter3 SRP-9001 dystrophin Transgene4-6 Affinity for muscle Specific to skeletal and cardiac muscle Assembles DAPC Relatively low level of preexisting immunity and favorable safety profile Enhanced expression in cardiac muscle Includes spectrin-like repeats 2 and 3 for maintenance of contractile force 1. Mendell JR, et al. Neurosci Lett 2012;627:90-99. 2. Chicoine LG, et al. Mol Ther 2014;22:713-724. 3. Salva MZ, et al. Mol Ther 2007;15:320-329. 4. Rodino-Klapac LR, et al. Hum Mol Genet 2013;22:4929-49375. Harper SQ, et al. Nat Med 2002;8:253-261. 6. Nelson DM, et al. Hum Mol Genet 2018;27:2090-2100.

Non-clinical proof-of-concept demonstrating a correlation between SRP-9001 dystrophin expression and strength output Skeletal Muscle Diaphragm Heart WT mdx 4.43 x 1013vg/kg 7.00 x 1014vg/kg 1.33 x 1014vg/kg 4.01 x 1014vg/kg Specific Force in TA Wt mdx-LR 1.33e14 4.01e14 vg/kg vg/kg P<0.01 P<0.01

SRP-9001 treatment leads to restoration of DAPC, reduced CK, and improved histopathology Wildtype DMDMDXuntreatedmice 1.33x1014vg/kg SRP-9001 SGCB Merged Serum Creatine Kinase Wt mdx 1.33e14 untreated vg/kg P<0.05

SRP-9001 dystrophin expression, transduction, and localization at the dose of 1.33 x 1014 vg/kg Measure Timepoint Study 101(Early Development Process) (n=4) Study 102 Part 1 & 2 Target Dose a (Early Development Process) (n=29) Study 103  (Intended Commercial Process) (n=20) Mean age (years) at time of biopsy W12 5.4 7.4 6.1 Vector Genome Copy Number b Mean change from Baseline to W12 (range) 3.3  2.9 3.4 (1.3 - 8.1) (0.3 - 7.3) (0.7-9.8) SRP-9001 Dystrophin Expression (western blot, % of normal expression) Mean change from Baseline to W12 (range) 74.3 38.6  54.2 (13.5 - 182.6) (-1.1 - 114.7) (4.8-153.9) IF Fiber Intensity (% control)  Mean change from Baseline to W12 (range) 93.6 c 61.6 66.5 (58.8 - 157.8) (-7.7 - 138.1) (-9.6 - 263.6) PDPF, %  Mean change from Baseline to W12 81.2 c 64.1 48.3 (73.5 - 96.2) (-7.3 - 96.1) (1.1 - 84.4) IF = immunofluorescent; PDPF = percent dystrophin positive fibers. Data extraction date: 9001-101: 15 June 2021; 9001-102: 12 May 2021; 9001-103: 09 February 2022 a Target Dose = 1.33 x 1014 vg/kg by ddPCR b qPCR was used to analyze vector genome copies in Study SRP-9001-101; ddPCR was used for Studies SRP‑9001-102 and ‑103. c IF and PDPF values in Study SRP-9001-101 were calculated using different methods than those used in SRP‑9001-102 and -103. Normal Control Pre-treatment Post-treatment β-Sarcoglycan Expression of DAPC Proteins in Muscle Fibers from the Gastrocnemius of Subject 4

Improved benefit over time1 1 year 1 year 1 year 2 year 4 year STUDY 102 Part 2 Integrated Efficacy Analysis at Target Dose STUDY 103 STUDY 102 Part 1 STUDY 101 20 patients 52 patients 20 patients 20 patients 4 patients Strong Expression Reduction in CK Positive Biomarkers 2.4 point3 3.2 point3 Vast body of pre-clinical and clinical data support SRP-9001 as disease-modifying All NSAA scores are compared to propensity-matched external control group. Calculated using least square means. Mendell, J. et al, WMS Conference 2022 and data on file. Calculated using least square means. Zaidman, C. et al, ICNMD Conference 2022 and data on file. Calculated using median. Data on file. Calculated using least square means. Mendell, J. et al, ICNMD Conference 2022 and data on file. 2 point2 5 point4 9.4 point5

SEPT OCT NOV DEC JAN FEB MAR APR MAY JUN SRP-9001 pathway BLA Filed BLA Accepted Priority Review Granted PDUFA Date (May 29, 2023) First Patient Treated SUMMER 2023 2022

Internal gene therapy capabilities complimented by partnerships: Meeting demand to launch SRP-9001 Dedicated Sarepta Facilities and Capabilities Analytical, Process Development & Quality Control Vector & drug product development Non-clinical tox manufacturing Fully equipped AD/QC labs Validated methods for tittering/release Continued Innovation and Improvement Approximately 140,000 sq. ft. for early research and development, as well as process development (Columbus, OH) Developing next-gen technologies to improve efficiencies and reduce COGS(e.g., suspension manufacturing process) Investments in FTEs and Infrastructure >30k ft2 facilities in Andover and Burlington, MA >300 dedicated staff for technical operations and manufacturing support Expanding gene therapy capacity in Bedford, MA facility External Partner Description Status Plasmid Production Dedicated capacity for Sarepta portfolio Vector Production(Drug Substance& Drug Product) Dedicated space for Sarepta Analytical Testing Dedicated FTEs to support Sarepta programs External Partnership Overview + Hybrid approach will drive competitive costs with continual improvements to drive upside

A holistic approach to assessing innovative treatments Quality adjusted life-years gained Net costs Adherence-improvingfactors Reductioninuncertainty Fear ofcontagion Insurancevalue Severity ofdisease Value ofhope Real-optionvalue VALUE Productivity Equity Scientificspillover Lakdawalla, et al. Defining Elements of Value in Health Care—A Health Economics Approach: An ISPOR Special Task Force Report [3], Value in Health, Volume 21, Issue 2, 2018, Pages 131-139. ISSN 1098-3015, https://doi.org/10.1016/j.jval.2017.12.007.

Robust total product revenue for RNA-based PMO franchise in Duchenne $ $ Millions 2019 2020 2021 2023 2022 $381M $456M $612M >$925M (Guidance) ~$2.0Bin cash on 12/31/22 (Unaudited) Revenues represent net product revenues from PMO franchise. $843.3M (Unaudited) Q4 revenue$235.5M(Unaudited)

Growth strategy: Leveraging current and future opportunities as we secure our leadership position in genetic medicine Proprietary technology platforms 3 Deep, advancing pipeline in neuromuscular, cardiac, and neuro to drive future growth 40+ programs 3 late-stage programs in Duchenne and limb-girdle muscular dystrophy type 2E Substantial revenue-generating base business Driven by on-market therapies 3 SRP-9001- lead gene therapy and possibility of 4th FDA-approved medicine With revenues approaching $1B RNA Gene Therapy Gene Editing $4B peak-year sales ~30 ‘22E ‘23E ‘24E ‘25E ‘26E Pathway to profitability $ clinical trialsongoing by year-end

But most importantly, we are enabling a future. ©Sarepta therapeutics, inc. 2023. All rights reserved.

Sarepta Therapeutics, Inc. (NASDAQ:SRPT) JPMorgan Healthcare Conference San Francisco, California January 9, 2023 Doug Ingram President and CEO

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Title of 12(b) Security	Common Stock, $0.0001 par value per share
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Security Exchange Name	NASDAQ