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Stock Based Compensation - Additional Information (Detail) - USD ($) $ / shares in Units, $ in Thousands	1 Months Ended	3 Months Ended		9 Months Ended
	Jun. 30, 2017	Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Stock-based compensation expense		$ 50,418	$ 26,684	$ 182,508	$ 84,161
Grants, Stock options		127,100	91,200	1,626,220	1,522,947
Chief Executive Officer
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Grants, Stock options	3,300,000
Minimum [Member]
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Compound annual growth rate				5.00%
Unvested Tranche Member
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Stock-based compensation expense		$ 20,500		$ 94,200
Incremental compensation cost				$ 29,400
Vesting, Stock options		550,110		550,110
Average closing price		$ 105.74		$ 105.74
Share-Based Compensation Arrangement by Share-Based Payment Award, Terms of Award				550,110 options relating to the Unvested Tranche met the conditions for vesting in that the average closing price of the Company's common stock exceeded $105.74 during 20 consecutive trading days in August 2022 and the compound annual growth rate of the Company's common stock exceeded that of the Nasdaq Biotech Index by greater than 5%