As of 
September 30,
2022

As of 
December 31,
2021

(in thousands)

Accrued contract manufacturing costs

$

190,343

$

104,311

Product revenue related reserves

67,942

62,145

Accrued employee compensation costs

42,689

48,299

Accrued clinical and pre-clinical costs

31,794

25,955

Accrued professional fees

13,888

9,381

Accrued royalties

7,862

11,965

Accrued income taxes

4,095

216

Accrued interest expense

2,935

1,045

Accrued collaboration cost sharing

1,868

2,887

Accrued sponsored research agreements

1,237

3,377

Other

4,345

2,116

Total accrued expenses

$

368,998

$

271,697