Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021
Cash flows from operating activities:
Net loss	$ (336,506)	$ (248,655)
Adjustments to reconcile net loss to cash flows from operating activities:
Depreciation and amortization	20,608	17,377
Reduction in the carrying amounts of the right of use assets	5,514	6,023
Non-cash interest expense	3,988	3,691
Stock-based compensation	132,090	57,477
Loss on disposal of assets	5,370	342
Gain from sale of Priority Review Voucher	0	(102,000)
Other	(991)	3,343
Changes in operating assets and liabilities, net:
Net increase in accounts receivable	(50,864)	(26,180)
Net increase in inventory	(15,364)	(36,795)
Net decrease in other assets	30,921	73,670
Net decrease in deferred revenue	(44,255)	(44,255)
Net decrease in accounts payable, accrued expenses, lease liabilities and other liabilities	81,499	6,445
Net cash used in operating activities	(167,990)	(289,517)
Cash flows from investing activities:
Purchase of property and equipment	(14,629)	(27,043)
Proceeds from sale of Priority Review Voucher, net of commission	0	102,000
Purchase of available-for-sale securities	(1,137,602)	(29,989)
Maturity and sale of available-for-sale securities	77,151	436,000
Other	(718)	(3,243)
Net cash (used in) provided by investing activities	(1,075,798)	477,725
Cash flows from financing activities:
Proceeds from exercise of stock options and purchase of stock under the Employee Stock Purchase Program	5,329	12,752
Taxes paid related to net share settlement of equity awards	0	(6,333)
Net cash provided by financing activities	5,329	6,419
Decrease in cash, cash equivalents and restricted cash	(1,238,459)	194,627
Cash, cash equivalents and restricted cash:
Beginning of period	2,125,523	1,511,713
End of period	887,064	1,706,340
Reconciliation of cash, cash equivalents and restricted cash:
Cash and cash equivalents	868,565	1,697,275
Restricted cash in other assets	18,499	9,065
Total cash, cash equivalents and restricted cash	887,064	1,706,340
Supplemental disclosure of cash flow information:
Cash paid during the period for interest	27,780	27,780
Supplemental schedule of non-cash investing activities and financing activities:
Intangible assets and property and equipment included in accounts payable and accrued expenses	5,751	7,760
Lease liabilities arising from obtaining right of use assets	11,407	10,582
Lease liabilities terminated	3,807	19,967
Shares withheld for tax included in accrued expenses	$ 0	$ 1,432