Condensed Consolidated Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Revenues:
Products, net	$ 211,237	$ 141,839	$ 400,062	$ 266,765
Type of Revenue [Extensible List]	us-gaap:ProductMember	us-gaap:ProductMember	us-gaap:ProductMember	us-gaap:ProductMember
Collaboration	$ 22,250	$ 22,250	$ 44,255	$ 44,255
Total revenues	233,487	164,089	444,317	311,020
Cost and expenses:
Cost of sales (excluding amortization of in-licensed rights)	37,795	19,515	69,238	41,861
Research and development	252,329	239,622	446,579	434,771
Selling, general and administrative	154,316	72,347	226,156	143,478
Settlement and license charges	0	0	0	10,000
Amortization of in-licensed rights	179	179	357	349
Total cost and expenses	444,619	331,663	742,330	630,459
Operating loss	(211,132)	(167,574)	(298,013)	(319,439)
Other (loss) income, net:
Other expense, net	(16,961)	(16,185)	(34,226)	(31,713)
Gain from sale of Priority Review Voucher	0	102,000	0	102,000
Total other (loss) income, net	(16,961)	85,815	(34,226)	70,287
Loss before income tax expense (benefit)	(228,093)	(81,759)	(332,239)	(249,152)
Income tax expense (benefit)	3,388	(354)	4,267	(497)
Net loss	(231,481)	(81,405)	(336,506)	(248,655)
Other comprehensive loss:
Unrealized (losses) gains on investments, net of tax	(2,179)	5	(2,465)	(1)
Total other comprehensive loss	(2,179)	5	(2,465)	(1)
Comprehensive loss	$ (233,660)	$ (81,400)	$ (338,971)	$ (248,656)
Net loss per share - basic and diluted	$ (2.65)	$ (1.02)	$ (3.85)	$ (3.12)
Net loss per share - basic and diluted	$ (2.65)	$ (1.02)	$ (3.85)	$ (3.12)
Weighted average number of shares of common stock used in computing basic and diluted net loss per share	87,511	79,746	87,383	79,601
Weighted average number of shares of common stock used in computing basic and diluted net loss per share	87,511	79,746	87,383	79,601