As of 
June 30,
2022

As of 
December 31,
2021

(in thousands)

Accrued contract manufacturing costs

$

204,867

$

104,311

Product revenue related reserves

68,361

62,145

Accrued clinical and pre-clinical costs

33,832

25,955

Accrued employee compensation costs

32,191

48,299

Accrued royalties

14,746

11,965

Accrued professional fees

13,574

9,381

Accrued collaboration cost sharing

2,868

2,887

Accrued income taxes

2,485

216

Accrued sponsored research agreements

1,651

3,377

Accrued fixed assets

1,462

127

Accrued interest expense

1,092

1,045

Other

6,570

1,989

Total accrued expenses

$

383,699

$

271,697