Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Cash flows from operating activities:
Net loss	$ (105,025)	$ (167,250)
Adjustments to reconcile net loss to cash flows from operating activities:
Depreciation and amortization	10,719	8,930
Reduction in the carrying amounts of the right of use assets	3,655	2,220
Non-cash interest expense	1,957	1,816
Stock-based compensation	29,198	28,508
Other	1,838	2,692
Changes in operating assets and liabilities, net:
Net increase in accounts receivable	(25,204)	(16,863)
Net increase in inventory	(4,687)	(8,372)
Net decrease (increase) in other assets	13,401	34,915
Net decrease in deferred revenue	(22,005)	(22,005)
Net decrease in accounts payable, accrued expenses, lease liabilities and other liabilities	(5,022)	(44,962)
Net cash used in operating activities	(101,175)	(180,371)
Cash flows from investing activities:
Purchase of property and equipment	(5,551)	(21,149)
Purchase of available-for-sale securities	(779,770)	(29,989)
Maturity and sale of available-for-sale securities		210,000
Other	(486)	(2,196)
Net cash (used in) provided by investing activities	(785,807)	156,666
Cash flows from financing activities:
Proceeds from exercise of stock options and purchase of stock under the Employee Stock Purchase Program	4,990	9,226
Taxes paid related to net share settlement of equity awards		6,333
Net cash provided by financing activities	4,990	2,893
Decrease in cash, cash equivalents and restricted cash	(881,992)	(20,812)
Cash, cash equivalents and restricted cash:
Beginning of period	2,125,523	1,511,713
End of period	1,243,531	1,490,901
Reconciliation of cash, cash equivalents and restricted cash:
Cash and cash equivalents	1,233,877	1,481,836
Restricted cash in other assets	9,654	9,065
Total cash, cash equivalents and restricted cash	1,243,531	1,490,901
Supplemental disclosure of cash flow information:
Cash paid during the period for interest	11,688	11,688
Supplemental schedule of non-cash investing activities and financing activities:
Intangible assets and property and equipment included in accounts payable and accrued expenses	4,415	5,729
Lease liabilities arising from obtaining right of use assets	4,106	901
Lease liabilities terminated	$ 0	$ 19,967