Summary of Accrued Expenses (Detail) - USD ($) $ in Thousands	Mar. 31, 2022	Dec. 31, 2021
Payables and Accruals [Abstract]
Accrued contract manufacturing costs	$ 138,179	$ 104,311
Product revenue related reserves	68,973	62,145
Accrued clinical and pre-clinical costs	34,554	25,955
Accrued employee compensation costs	19,177	48,299
Accrued royalties	12,980	11,965
Accrued professional fees	10,644	9,381
Accrued interest expense	3,182	1,045
Accrued collaboration cost sharing	2,263	2,887
Other	3,956	5,709
Total accrued expenses	$ 293,908	$ 271,697