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Summary of Other Non-current Assets (Detail) - USD ($)
$ in Thousands
Mar. 31, 2022
Dec. 31, 2021
Prepaid Expense and Other Assets, Noncurrent [Abstract]    
Non-current inventory $ 121,423 $ 129,521
Manufacturing-related deposits and prepaids 108,363 112,765
Strategic investments 33,394 34,892
Restricted cash and investments 9,654 9,904
Prepaid clinical expenses 2,080 2,007
Other 3,735 3,860
Total other non-current assets $ 278,649 $ 292,949