Condensed Consolidated Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Revenues:
Products, net	$ 188,825	$ 124,926
Type of Revenue [Extensible List]	us-gaap:ProductMember	us-gaap:ProductMember
Collaboration	$ 22,005	$ 22,005
Total revenues	210,830	146,931
Cost and expenses:
Cost of sales (excluding amortization of in-licensed rights)	31,443	22,346
Research and development	194,250	195,149
Selling, general and administrative	71,840	71,131
Settlement and license charges	0	10,000
Amortization of in-licensed rights	178	170
Total cost and expenses	297,711	298,796
Operating loss	(86,881)	(151,865)
Other loss, net:
Other expense, net	(17,265)	(15,528)
Total other loss, net	(17,265)	(15,528)
Loss before income tax expense (benefit)	(104,146)	(167,393)
Income tax expense (benefit)	879	(143)
Net loss	(105,025)	(167,250)
Other comprehensive loss:
Unrealized losses on investments, net of tax	(286)	(6)
Total other comprehensive loss	(286)	(6)
Comprehensive loss	$ (105,311)	$ (167,256)
Net loss per share - basic and diluted	$ (1.20)	$ (2.10)
Weighted average number of shares of common stock used in computing basic and diluted net loss per share	87,253	79,454