Condensed Consolidated Balance Sheets - USD ($) $ in Thousands	Mar. 31, 2022	Dec. 31, 2021
Current assets:
Cash and cash equivalents	$ 1,233,877	$ 2,115,869
Short-term investments	779,548	0
Accounts receivable	178,194	152,990
Inventory	198,997	186,212
Other current assets	140,331	149,028
Total current assets	2,530,947	2,604,099
Property and equipment, net	187,248	191,156
Intangible assets, net	13,328	14,239
Right of use assets	45,982	45,531
Other non-current assets	278,649	292,949
Total assets	3,056,154	3,147,974
Current liabilities:
Accounts payable	54,007	76,741
Accrued expenses	293,908	271,697
Deferred revenue, current portion	89,244	89,244
Other current liabilities	17,803	15,051
Total current liabilities	454,962	452,733
Long-term debt	1,098,847	1,096,876
Lease liabilities, net of current portion	38,620	41,512
Deferred revenue, net of current portion	552,239	574,244
Contingent consideration	43,600	43,600
Other non-current liabilities	11,000	11,000
Total liabilities	2,199,268	2,219,965
Commitments and contingencies (Note 13)
Stockholders’ equity:
Preferred stock, $0.0001 par value, 3,333,333 shares authorized; none issued and outstanding	0	0
Common stock, $0.0001 par value, 198,000,000 shares authorized; 87,495,607 and 87,126,974 issued and outstanding at March 31, 2022, and December 31, 2021, respectively	9	9
Additional paid-in capital	4,168,956	4,134,768
Accumulated other comprehensive loss, net of tax	(306)	(20)
Accumulated deficit	(3,311,773)	(3,206,748)
Total stockholders’ equity	856,886	928,009
Total liabilities and stockholders’ equity	$ 3,056,154	$ 3,147,974