Summary of product revenues, net by product (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Product Information [Line Items]
Product revenues, net	$ 612,401	$ 455,865	$ 380,833
EXONDYS 51 [Member]
Product Information [Line Items]
Product revenues, net	454,361	422,007	380,718
VYONDYS 53 [Member]
Product Information [Line Items]
Product revenues, net	89,511	33,858	115
AMONDYS 45 [Member]
Product Information [Line Items]
Product revenues, net	$ 68,529