INCOME TAXES (Tables)

12 Months Ended

Dec. 31, 2021

Income Tax Disclosure [Abstract]

Summary of Loss before Provision (Benefit) for Income Taxes by Jurisdiction

The following table summarizes the loss before the provision (benefit) for income taxes by jurisdiction for the periods indicated:

	For the Year Ended December 31,
	2021			2020			2019
	(in thousands)
Domestic	$	(47,633	)	$	(204,956	)	$	(489,747	)
Foreign		(371,315	)		(348,109	)		(224,133	)
Total	$	(418,948	)	$	(553,065	)	$	(713,880	)

Summary of Provision (Benefit) for Income Taxes

The following table summarizes provision (benefit) for income taxes in the accompanying consolidated financial statements for the periods indicated:

	For the Year Ended December 31,
	2021			2020			2019
	(in thousands)
Current provision:
Federal	$	—		$	4		$	—
State		(40	)		624			521
Foreign		181			680			1,050
Total current provision		141			1,308			1,571
Deferred benefit:
Federal		—			—			(15	)
State		—			—			(5	)
Foreign		(309	)		(245	)		(356	)
Total deferred benefit		(309	)		(245	)		(376	)
Total income tax (benefit) expense	$	(168	)	$	1,063		$	1,195

Reconciliation Between Effective Tax Rate and Statutory Income Tax Rate

The following table summarizes the reconciliation between the Company’s effective tax rate and the statutory income tax rate for each of the periods indicated:

	For the Year Ended December 31,
	2021				2020				2019
Federal income tax rate		21.0		%		21.0		%		21.0		%
State taxes		0.4				0.6				4.5
Research and development and other tax    credits		10.0				10.1				5.1
Valuation allowance		(9.8	)			(21.3	)			(16.8	)
Permanent differences		(0.3	)			(1.6	)			2.3
Stock-based compensation		(3.0	)			3.5				(0.6	)
Basis difference in subsidiary		—				—				(8.4	)
Foreign rate differential		(18.4	)			(12.9	)			(7.4	)
Other		0.1				0.4				0.1
Effective tax rate		(0.0	)	%		(0.2	)	%		(0.2	)	%

Analysis of Deferred Tax Assets and Liabilities

The following table summarizes the analysis of the deferred tax assets and liabilities for each of the periods indicated:

	As of December 31,
	2021			2020
	(in thousands)
Deferred tax assets:
Net operating loss carryforwards	$	330,392		$	333,703
Difference in depreciation and amortization		31,563			31,259
Research and development tax credits		201,512			159,917
Stock-based compensation		38,132			31,212
Lease liabilities		10,890			13,120
Capitalized inventory		24,172			35,959
Debt discount		5,875			—
Other		38,315			28,381
Total deferred tax assets		680,851			633,551
Deferred tax liabilities:
Right of use asset		(7,405	)		(8,772	)
Debt discount		—			(18,044	)
Total deferred tax liabilities		(7,405	)		(26,816	)
Valuation allowance		(672,319	)		(605,848	)
Net deferred tax assets	$	1,127		$	887

Reconciliation of Beginning and Ending Amount of Unrecognized Tax Benefits

The follow table summarizes the reconciliation of the beginning and ending amount of total unrecognized tax benefits for each of the periods indicated:

	For the Year Ended December 31,
	2021			2020		2019
	(in thousands)
Balance at beginning of the period	$	48,475		$	41,753	$	37,544
Increase related to current year tax positions		5,503			6,722		4,275
Increase related to prior year tax positions		—			—		109
Decrease related to prior year tax positions		(163	)		—		(175	)
Balance at end of the period	$	53,815		$	48,475	$	41,753