Consolidated Balance Sheets - USD ($) $ in Thousands	Dec. 31, 2021	Dec. 31, 2020
Current assets:
Cash and cash equivalents	$ 2,115,869	$ 1,502,648
Short-term investments		435,923
Accounts receivable	152,990	101,340
Inventory	186,212	231,961
Other current assets	149,028	213,324
Total current assets	2,604,099	2,485,196
Property and equipment, net	191,156	190,430
Intangible assets, net	14,239	13,628
Right of use assets	45,531	91,761
Other non-current assets	292,949	203,703
Total assets	3,147,974	2,984,718
Current liabilities:
Accounts payable	76,741	111,090
Accrued expenses	271,697	193,553
Deferred revenue, current portion	89,244	89,244
Other current liabilities	15,051	22,139
Total current liabilities	452,733	416,026
Long-term debt	1,096,876	992,493
Lease liabilities, net of current portion	41,512	80,367
Deferred revenue, net of current portion	574,244
Contingent consideration	43,600	50,800
Other non-current liabilities	11,000	19,785
Total liabilities	2,219,965	2,222,959
Commitments and contingencies (Note 21)
Stockholders’ equity:
Preferred stock, $.0001 par value, 3,333,333 shares authorized; none issued and outstanding
Common stock, $.0001 par value, 198,000,000 shares authorized; 87,126,974 and 79,374,247 issued and outstanding at December 31, 2021 and 2020, respectively	9	8
Additional paid-in capital	4,134,768	3,609,877
Accumulated other comprehensive (loss) income, net of tax	20	3
Accumulated deficit	(3,206,748)	(2,848,129)
Total stockholders’ equity	928,009	761,759
Total liabilities and stockholders’ equity	$ 3,147,974	$ 2,984,718