ACCRUED EXPENSES

12 Months Ended

Dec. 31, 2021

Payables and Accruals [Abstract]

ACCRUED EXPENSES

12. ACCRUED EXPENSES

The following table summarizes the Company’s accrued expenses for each of the periods indicated:

	As of December 31,
	2021		2020
	(in thousands)
Accrued contract manufacturing costs	$	104,311	$	36,543
Product revenue related reserves		62,145		42,618
Accrued employee compensation costs		48,299		50,803
Accrued clinical and pre-clinical costs		25,955		22,169
Accrued royalties		11,965		7,793
Accrued professional fees		9,381		10,221
Accrued collaboration cost-sharing		2,887		3,516
Accrued interest expense		1,045		1,045
Accrued milestone and license expense		100		9,380
Other		5,609		9,465
Total accrued expenses	$	271,697	$	193,553