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Document and Entity Information - USD ($)
 12 Months Ended
Dec. 31, 2021
Feb. 24, 2022
Jun. 30, 2021
Cover [Abstract]      
Document Type 10-K    
Amendment Flag false    
Document Period End Date Dec. 31, 2021    
Document Fiscal Year Focus 2021    
Document Fiscal Period Focus FY    
Trading Symbol SRPT    
Entity Registrant Name Sarepta Therapeutics, Inc.    
Entity Central Index Key 0000873303    
Current Fiscal Year End Date --12-31    
Entity Well-known Seasoned Issuer Yes    
Entity Current Reporting Status Yes    
Entity Voluntary Filers No    
Entity Filer Category Large Accelerated Filer    
Entity Small Business false    
Entity Emerging Growth Company false    
Entity Shell Company false    
ICFR Auditor Attestation Flag false    
Entity File Number 001-14895    
Entity Tax Identification Number 93-0797222    
Entity Incorporation, State or Country Code DE    
Entity Address, Address Line One 215 First Street    
Entity Address, Address Line Two Suite 415    
Entity Address, City or Town Cambridge    
Entity Address, State or Province MA    
Entity Address, Postal Zip Code 02142    
City Area Code 617    
Local Phone Number 274-4000    
Entity Interactive Data Current Yes    
Title of 12(b) Security Common Stock, $0.0001 par value    
Security Exchange Name NASDAQ    
Document Annual Report true    
Document Transition Report false    
Entity Common Stock, Shares Outstanding   87,149,589  
Entity Public Float     $ 6,206,016,151
Documents Incorporated by Reference

The registrant has incorporated by reference into Part II and Part III of this Annual Report on Form 10-K portions of its definitive Proxy Statement for the 2022 Annual Meeting of Stockholders to be filed no later than 120 days after the end of the fiscal year covered by this Annual Report on Form 10-K.

    
Auditor Name KPMG LLP    
Auditor Location Boston, Massachusetts    
Auditor Firm ID 185