Summary of Accrued Expenses (Detail) - USD ($) $ in Thousands	Sep. 30, 2021	Dec. 31, 2020
Payables And Accruals [Abstract]
Accrued contract manufacturing costs	$ 69,055	$ 36,543
Product revenue related reserves	59,942	42,618
Accrued employee compensation costs	29,725	50,803
Accrued clinical and pre-clinical costs	27,942	22,169
Accrued royalties	11,142	7,793
Accrued professional fees	8,929	10,221
Accrued collaboration cost sharing	4,927	3,516
Accrued interest expense	3,182	1,045
Accrued property and equipment	130	4,993
Accrued milestone and license expense		9,380
Other	6,035	4,472
Total accrued expenses	$ 221,009	$ 193,553