INTERNAL CONTROL RPT

REPORT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

To the Shareholders and the Board of Directors of American Century World Mutual Funds, Inc.:

In planning and performing our audits of the financial statements of American Century World Mutual Funds, Inc. (the “Corporation”), including Emerging Markets Fund, Emerging Markets Small Cap Fund, Focused Global Growth Fund, Focused International Growth Fund, Global Small Cap Fund, International Growth Fund, International Opportunities Fund, International Value Fund, Non-U.S. Intrinsic Value Fund, NT Emerging Markets Fund, NT International Growth Fund, NT International Small-Mid Cap Fund, and NT International Value Fund, as of and for the year ended November 30, 2021, in accordance with the standards of the Public Company Accounting Oversight Board (United States) (PCAOB), we considered the Corporation’s internal control over financial reporting, including controls over safeguarding securities, as a basis for designing our auditing procedures for the purpose of expressing our opinion on the financial statements and to comply with the requirements of Form N-CEN, but not for the purpose of expressing an opinion on the effectiveness of the Corporation’s internal control over financial reporting. Accordingly, we express no such opinion.

The management of the Corporation is responsible for establishing and maintaining effective internal control over financial reporting. In fulfilling this responsibility, estimates and judgments by management are required to assess the expected benefits and related costs of controls. A company's internal control over financial reporting is a process designed to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles. A company's internal control over financial reporting includes those policies and procedures that (1) pertain to the maintenance of records that, in reasonable detail, accurately and fairly reflect the transactions and dispositions of the assets of the company; (2) provide reasonable assurance that transactions are recorded as necessary to permit preparation of financial statements in accordance with generally accepted accounting principles, and that receipts and expenditures of the company are being made only in accordance with authorizations of management and directors of the company; and (3) provide reasonable assurance regarding prevention or timely detection of unauthorized acquisition, use, or disposition of a company's assets that could have a material effect on the financial statements.

Because of its inherent limitations, internal control over financial reporting may not prevent or detect misstatements. Also, projections of any evaluation of effectiveness to future periods are subject to the risk that controls may become inadequate because of changes in conditions or that the degree of compliance with the policies or procedures may deteriorate.

A deficiency in internal control over financial reporting exists when the design or operation of a control does not allow management or employees, in the normal course of performing their assigned functions, to prevent or detect misstatements on a timely basis. A material weakness is a deficiency, or a combination of deficiencies, in internal control over financial reporting, such that there is a reasonable possibility that a material misstatement of the company's annual or interim financial statements will not be prevented or detected on a timely basis.

Our consideration of the Corporation’s internal control over financial reporting was for the limited purpose described in the first paragraph and would not necessarily disclose all deficiencies in internal control that might be material weaknesses under standards established by the PCAOB. However, we noted no deficiencies in the Corporation’s internal control over financial reporting and its operation, including controls for safeguarding securities, that we consider to be a material weakness, as defined above, as of November 30, 2021.

This report is intended solely for the information and use of management and the Board of Directors of the Corporation and the Securities and Exchange Commission and is not intended to be and should not be used by anyone other than these specified parties.

/s/ Deloitte & Touche LLP

Kansas City, Missouri

January 19, 2022

OTHER REQUIRED INFO

Pursuant to the Fund’s procedures adopted under Rule 10f-3, the Fund’s Board of Directors/Trustees receives a quarterly report in the form of a checklist as to the satisfaction of the applicable conditions of paragraph (c)(1) through (c)(8) of Rule 10f-3.

Fund	Global Small Cap
Issuer	Ortho Clinical Diagnostics Holdings Plc
Ticker/Sedol	OCDX (99080X0A1)
Principal Amount (US$)	$1,292,000,000
Principal Amount (Foreign$)	NA
Amount Purchased (US$)	$341,683
Amount Purchased (Foreign$)	NA
Trade Date	01/28/2021
Price (US$)	$17.00
Price-Foreign	NA
Underwriter	JP Morgan Securities
Other Syndicate Members:	BANK OF AMERICA MERRILL BARCLAYS CAPITAL CITIGROUP CAPITAL MARKETS CREDIT SUISSE DREXEL HAMILTON, LLC GOLDMAN SACHS ING INSTINET-OVER THE COUNTER INSTINET HOLDINGS EVERCORE ISI MACQUARIE SECURITIES MORGAN STANLEY SIEBERT WILLIAMS SHANK NOMURA SECURITIES PIPER SANDLER & CO SAMUEL RAMIREZ & CO INC UBS WARBURG TCG BDC Inc HC WAINWRIGHT
Underwriting Spread	4.00%
Currency	USD

Fund	Global Small Cap
Issuer	Appier Group Inc.
Ticker/Sedol	4180.T (BMH40Q4)
Principal Amount (US$)	$273,763,897
Principal Amount (Foreign$)	JPY 29,811,520,000
Amount Purchased (US$)	$102,851.37
Amount Purchased (Foreign$)	JPY 11,200,000
Trade Date	3/22/2021
Price (US$)	$14.69
Price-Foreign	JPY 1,600
Underwriter	Mizuho
Other Syndicate Members:	SMBC Nikko, BofA Securities, UBS AG, Merrill Lynch International, Nomura Securities, Rakuten Securities, SBI Securities, UBS Securities Ltd
Underwriting Spread	7.00%
Currency	JPY

Fund	Global Small Cap
Issuer	Sterling Check Corp
Ticker/Sedol	STER (85917T109)
Principal Amount (US$)	$328,670,000
Principal Amount (Foreign$)	NA
Amount Purchased (US$)	$192,395
Amount Purchased (Foreign$)	NA
Trade Date	9/23/2021
Price (US$)	$23.00
Price-Foreign	NA
Underwriter	Godman Sachs
Other Syndicate Members:	J.P. Morgan Morgan Stanley Baird William Blair KeyBanc Capital Markets Nomura Stifel
Underwriting Spread	6.25%
Currency	USD

Fund	Global Small Cap
Issuer	Fluence Energy Inc
Ticker/Sedol	FLNC (34379V103)
Principal Amount (US$)	$868,000,000
Principal Amount (Foreign$)	NA
Amount Purchased (US$)	$119,672
Amount Purchased (Foreign$)	NA
Trade Date	10/28/2021
Price (US$)	$28.00
Price-Foreign	NA
Underwriter	Morgan Stanley
Other Syndicate Members:	JP Morgan Barclays Capital BofA Securities Citigroup Global Markets Inc Credit Suisse Evercore ISI HSBC Securities UBS Investment Bank Nomura Securities International Penserra Securities LLC RBC Capital Markets Raymond James & Associates Robert W Baird & Co Seaport Global Siebert Williams Shank & Co
Underwriting Spread	3.42%
Currency	USD

Fund	Global Small Cap
Issuer	Remitly Global Inc
Ticker/Sedol	RELY (75960P104)
Principal Amount (US$)	$522,880,000
Principal Amount (Foreign$)	N/A
Amount Purchased (US$)	$121,002
Amount Purchased (Foreign$)	N/A
Trade Date	9/23/2021
Price (US$)	$43.00
Price-Foreign	N/A
Underwriter	Goldman Sachs & Co
Other Syndicate Members:	J.P. Morgan Securities, Barclays Capital Inc, Citigroup Global Markets Inc, William Blair & Company, JMP Securities, Keybanc Capital Markets, Nomura Securities International
Underwriting Spread	5.50%
Currency	USD