a
a
Country
Shares
a
Value
a
a
a
a
a
a
Common
Stocks
93.6%
Biotechnology
70.0%
a
89bio,
Inc.
...........................................
United
States
254,237
$
2,516,946
a
Abivax
SA
,
ADR
......................................
France
487,700
6,427,886
a
ACELYRIN,
Inc.
......................................
United
States
257,390
1,961,312
a
Acumen
Pharmaceuticals,
Inc.
...........................
United
States
674,000
2,143,320
a
Adverum
Biotechnologies,
Inc.
...........................
United
States
1,206,300
1,266,615
a
Alector,
Inc.
..........................................
United
States
303,345
1,807,936
a
Alpine
Immune
Sciences,
Inc.
............................
United
States
387,374
10,308,022
Amgen,
Inc.
.........................................
United
States
243,111
76,400,063
a
AnaptysBio,
Inc.
......................................
United
States
127,523
3,009,543
a
Apellis
Pharmaceuticals,
Inc.
.............................
United
States
77,479
4,903,646
a
Apogee
Therapeutics,
Inc.
...............................
United
States
163,539
5,478,557
a
Applied
Therapeutics,
Inc.
...............................
United
States
1,876,254
5,872,675
a,b
Arcutis
Biotherapeutics,
Inc.
.............................
United
States
1,539,452
9,036,583
a
Argenx
SE
,
ADR
......................................
Netherlands
44,485
16,926,987
a,b
ARS
Pharmaceuticals,
Inc.
..............................
United
States
1,378,589
8,561,038
a
Ascendis
Pharma
A/S
,
ADR
.............................
Denmark
260,974
33,908,352
a
Aura
Biosciences,
Inc.
..................................
United
States
282,300
2,173,710
a
Benitec
Biopharma,
Inc.
................................
Australia
364,887
1,025,332
a
Biogen,
Inc.
.........................................
United
States
129,344
31,903,991
a
BioMarin
Pharmaceutical,
Inc.
............................
United
States
46,289
4,077,135
a,b
Cargo
Therapeutics,
Inc.
................................
United
States
172,162
3,789,286
a,c
Carmot
Therapeutics,
Inc.
...............................
United
States
83,100
219,463
a
Centessa
Pharmaceuticals
plc
,
ADR
.......................
United
States
189,736
1,553,938
a,b
Centessa
Pharmaceuticals
plc
,
ADR
.......................
United
States
165,029
1,351,587
a
CG
oncology,
Inc.
.....................................
United
States
101,600
3,785,616
a
Crinetics
Pharmaceuticals,
Inc.
...........................
United
States
130,922
4,776,035
a
Cullinan
Oncology,
Inc.
.................................
United
States
783,020
11,854,923
a
Cytokinetics,
Inc.
......................................
United
States
49,024
3,830,245
a
Day
One
Biopharmaceuticals,
Inc.
.........................
United
States
908,581
13,674,144
a
Disc
Medicine,
Inc.
....................................
United
States
68,425
4,498,944
a
Dyne
Therapeutics,
Inc.
................................
United
States
355,434
7,606,288
a
Fusion
Pharmaceuticals,
Inc.
.............................
Canada
89,100
1,035,342
Gilead
Sciences,
Inc.
..................................
United
States
413,900
32,391,814
a,b
Heron
Therapeutics,
Inc.
................................
United
States
1,195,377
2,880,859
a
HilleVax,
Inc.
.........................................
United
States
619,656
8,780,526
a
Immunovant,
Inc.
.....................................
United
States
207,713
7,562,830
a
Insmed,
Inc.
.........................................
United
States
704,740
19,591,772
a
Jasper
Therapeutics,
Inc.
...............................
United
States
144,574
1,703,082
a
Keros
Therapeutics,
Inc.
................................
United
States
220,450
12,204,112
a
Kura
Oncology,
Inc.
....................................
United
States
267,682
5,391,115
a
Legend
Biotech
Corp.
,
ADR
.............................
United
States
122,034
6,719,192
a
Merus
NV
...........................................
Netherlands
447,826
15,978,432
a
Mineralys
Therapeutics,
Inc.
.............................
United
States
279,548
3,049,869
a
Mirum
Pharmaceuticals,
Inc.
.............................
United
States
312,590
8,271,131
a
Neurocrine
Biosciences,
Inc.
.............................
United
States
166,630
23,289,875
a
Nuvalent,
Inc.
,
A
......................................
United
States
57,554
4,326,334
a
ORIC
Pharmaceuticals,
Inc.
.............................
United
States
234,001
2,571,671
a
PTC
Therapeutics,
Inc.
.................................
United
States
480,611
12,539,141
a
Regeneron
Pharmaceuticals,
Inc.
.........................
United
States
64,771
61,064,803
a
Rocket
Pharmaceuticals,
Inc.
............................
United
States
345,346
9,921,791
a
Roivant
Sciences
Ltd.
..................................
United
States
197,900
1,979,000
a
Sarepta
Therapeutics,
Inc.
..............................
United
States
75,552
8,989,932
a,b
Shattuck
Labs,
Inc.
....................................
United
States
527,104
4,975,862
a
Spyre
Therapeutics,
Inc.
................................
United
States
220,000
5,700,200
a
Syndax
Pharmaceuticals,
Inc.
............................
United
States
278,900
5,714,661
a
Ultragenyx
Pharmaceutical,
Inc.
..........................
United
States
63,321
2,793,089
a
Vaxcyte,
Inc.
.........................................
United
States
193,739
13,836,839
a
Vertex
Pharmaceuticals,
Inc.
.............................
United
States
123,040
53,323,075