a
a
Country
Shares
a
Value
a
a
a
a
a
a
Common
Stocks
97.7%
Biotechnology
73.3%
a
89bio,
Inc.
...........................................
United
States
254,237
$
4,027,114
a
ACELYRIN,
Inc.
......................................
United
States
280,090
6,957,436
a,b
Acumen
Pharmaceuticals,
Inc.
...........................
United
States
491,900
3,640,060
a
Alector,
Inc.
..........................................
United
States
303,345
2,080,947
Amgen,
Inc.
.........................................
United
States
228,082
53,405,401
a
Apogee
Therapeutics,
Inc.
...............................
United
States
140,457
3,005,780
a,b,c
Applied
Therapeutics,
Inc.
...............................
United
States
2,584,054
4,599,616
a
Arcutis
Biotherapeutics,
Inc.
.............................
United
States
402,520
4,391,493
a
Argenx
SE,
ADR
......................................
Netherlands
68,085
34,347,521
a
Ascendis
Pharma
A/S,
ADR
.............................
Denmark
309,111
27,866,357
a
Avidity
Biosciences,
Inc.
................................
United
States
109,386
1,040,261
a,b,c
Benitec
Biopharma,
Inc.
................................
Australia
364,886
1,123,849
a
Biogen,
Inc.
.........................................
United
States
152,922
41,317,995
a
BioMarin
Pharmaceutical,
Inc.
............................
United
States
259,989
22,860,833
a,b
Candel
Therapeutics,
Inc.
...............................
United
States
400,800
432,864
a,b
Centessa
Pharmaceuticals
plc,
ADR
.......................
United
States
278,993
2,204,045
a
Crinetics
Pharmaceuticals,
Inc.
...........................
United
States
43,322
823,118
a
CRISPR
Therapeutics
AG
...............................
Switzerland
72,193
4,138,825
a
Cullinan
Oncology,
Inc.
.................................
United
States
590,557
6,253,999
a
Cytokinetics,
Inc.
......................................
United
States
232,424
7,751,340
a
Day
One
Biopharmaceuticals,
Inc.
.........................
United
States
908,581
12,029,612
a,b
Disc
Medicine,
Inc.
....................................
United
States
50,325
2,496,120
a
Dyne
Therapeutics,
Inc.
................................
United
States
355,434
4,329,186
a
Equillium,
Inc.
........................................
United
States
294,800
218,152
Gilead
Sciences,
Inc.
..................................
United
States
516,365
39,316,031
a
Harpoon
Therapeutics,
Inc.
..............................
United
States
445,299
348,803
a
Heron
Therapeutics,
Inc.
................................
United
States
1,739,677
2,887,864
a
HilleVax,
Inc.
.........................................
United
States
423,056
6,438,912
a
Insmed,
Inc.
.........................................
United
States
780,500
17,241,245
a
Jasper
Therapeutics,
Inc.
...............................
United
States
1,439,300
2,173,343
a
Karuna
Therapeutics,
Inc.
...............................
United
States
38,051
7,601,448
a
Keros
Therapeutics,
Inc.
................................
United
States
153,551
6,430,716
a
Kezar
Life
Sciences,
Inc.
................................
United
States
449,150
1,006,096
a
Kura
Oncology,
Inc.
....................................
United
States
178,292
1,861,369
a
Legend
Biotech
Corp.,
ADR
.............................
United
States
134,634
10,167,560
a
Merus
NV
...........................................
Netherlands
404,226
10,606,890
a,b
Mineralys
Therapeutics,
Inc.
.............................
United
States
143,600
2,029,068
a
Mirati
Therapeutics,
Inc.
................................
United
States
132,023
3,996,336
a
Mirum
Pharmaceuticals,
Inc.
.............................
United
States
236,190
6,084,254
a
Moderna,
Inc.
........................................
United
States
67,390
7,929,107
a,b
MoonLake
Immunotherapeutics,
A
.........................
United
States
67,535
4,106,803
a
Neurocrine
Biosciences,
Inc.
.............................
United
States
177,673
18,103,102
a
Nuvalent,
Inc.,
A
......................................
United
States
17,163
855,576
a
PTC
Therapeutics,
Inc.
.................................
United
States
643,974
25,977,911
a
Regeneron
Pharmaceuticals,
Inc.
.........................
United
States
68,033
50,474,363
a,b
Reneo
Pharmaceuticals,
Inc.
.............................
United
States
429,233
3,446,741
a
Rocket
Pharmaceuticals,
Inc.
............................
United
States
217,526
3,926,344
a
Roivant
Sciences
Ltd.
..................................
United
States
531,068
6,362,195
a
Sage
Therapeutics,
Inc.
................................
United
States
75,830
2,629,784
a
Sarepta
Therapeutics,
Inc.
..............................
United
States
66,852
7,246,088
a
Seagen,
Inc.
.........................................
United
States
116,366
22,316,671
a
Sutro
Biopharma,
Inc.
..................................
United
States
564,189
2,521,925
a
Taysha
Gene
Therapies,
Inc.
.............................
United
States
304,256
204,825
a
Ultragenyx
Pharmaceutical,
Inc.
..........................
United
States
60,696
2,617,212
a
Vaxcyte,
Inc.
.........................................
United
States
176,239
8,470,046
a
Vertex
Pharmaceuticals,
Inc.
.............................
United
States
168,394
59,331,942