a
a
Country
Shares
a
Value
a
a
a
a
a
a
Common
Stocks
97.2%
Biotechnology
75.0%
a
Albireo
Pharma,
Inc.
...................................
United
States
301,243
$
6,262,842
a
Alector
,
Inc.
..........................................
United
States
399,945
4,087,438
Amgen,
Inc.
.........................................
United
States
259,360
64,183,819
a
Applied
Molecular
Transport,
Inc.
.........................
United
States
138,000
262,200
a
Applied
Therapeutics,
Inc.
...............................
United
States
1,575,654
1,701,706
a
Arcutis
Biotherapeutics
,
Inc.
.............................
United
States
141,456
3,431,723
a
Argenx
SE,
ADR
......................................
Netherlands
58,158
21,181,725
a
Ascendis
Pharma
A/S,
ADR
.............................
Denmark
298,600
25,539,258
a,b
BELLUS
Health,
Inc.
...................................
Canada
587,700
5,765,337
a
Biogen,
Inc.
.........................................
United
States
133,875
28,791,157
a
BioMarin
Pharmaceutical,
Inc.
............................
United
States
142,456
12,258,339
a
Candel
Therapeutics,
Inc.
...............................
United
States
400,800
1,242,480
a,b
Centessa
Pharmaceuticals
plc,
ADR
.......................
United
States
278,993
1,205,250
a
Codiak
Biosciences,
Inc.
................................
United
States
72,452
189,824
a
CRISPR
Therapeutics
AG
...............................
Switzerland
106,514
7,988,550
a
Cullinan
Oncology,
Inc.
.................................
United
States
113,700
1,536,087
a
Cytokinetics,
Inc.
......................................
United
States
254,100
10,756,053
a
Day
One
Biopharmaceuticals,
Inc.
.........................
United
States
546,133
9,355,258
a
Dyne
Therapeutics,
Inc.
................................
United
States
355,434
3,728,503
a
Equillium
,
Inc.
........................................
United
States
294,800
651,508
a
Fate
Therapeutics,
Inc.
.................................
United
States
222,810
6,802,389
Gilead
Sciences,
Inc.
..................................
United
States
614,827
36,735,913
a
Harpoon
Therapeutics,
Inc.
..............................
United
States
445,299
868,333
a
Heron
Therapeutics,
Inc.
................................
United
States
1,739,677
4,836,302
a,c,d
HilleVax
,
Inc.
.........................................
United
States
202,922
2,341,174
a,b
HilleVax
,
Inc.
.........................................
United
States
220,134
2,976,212
a
Horizon
Therapeutics
plc
................................
United
States
526,871
43,714,487
a
Insmed
,
Inc.
.........................................
United
States
780,500
17,264,660
a
Iovance
Biotherapeutics
,
Inc.
.............................
United
States
1,395,901
16,262,247
a
IVERIC
bio,
Inc.
......................................
United
States
419,108
4,480,265
a
Karuna
Therapeutics,
Inc.
...............................
United
States
43,937
5,722,794
a
Keros
Therapeutics,
Inc.
................................
United
States
153,551
4,925,916
a
Kezar
Life
Sciences,
Inc.
................................
United
States
449,150
4,388,196
a
Legend
Biotech
Corp.,
ADR
.............................
United
States
159,125
7,517,065
a
LogicBio
Therapeutics,
Inc.
..............................
United
States
120,913
47,458
a
Merus
NV
...........................................
Netherlands
280,694
6,787,181
a
Mirati
Therapeutics,
Inc.
................................
United
States
319,821
20,596,472
a
Moderna
,
Inc.
........................................
United
States
97,615
16,017,645
a
Neurocrine
Biosciences,
Inc.
.............................
United
States
177,673
16,724,359
a,b
Novavax
,
Inc.
........................................
United
States
59,882
3,264,168
a,b
Pardes
Biosciences,
Inc.
................................
United
States
74,431
209,895
a
Prometheus
Biosciences,
Inc.
............................
United
States
178,787
7,628,841
a
PTC
Therapeutics,
Inc.
.................................
United
States
667,774
29,081,558
a
Regeneron
Pharmaceuticals,
Inc.
.........................
United
States
69,833
40,621,158
a,b
Reneo
Pharmaceuticals,
Inc.
.............................
United
States
158,423
559,233
a
Rocket
Pharmaceuticals,
Inc.
............................
United
States
217,526
3,154,127
a
Sage
Therapeutics,
Inc.
................................
United
States
101,070
3,477,819
a
Seagen
,
Inc.
.........................................
United
States
180,710
32,524,186
a
Sutro
Biopharma,
Inc.
..................................
United
States
916,889
5,363,801
a
Taysha
Gene
Therapies,
Inc.
.............................
United
States
304,256
1,238,322
a
Ultragenyx
Pharmaceutical,
Inc.
..........................
United
States
60,696
3,233,883
a
Vertex
Pharmaceuticals,
Inc.
.............................
United
States
234,058
65,632,203
a
VistaGen
Therapeutics,
Inc.
.............................
United
States
2,977,111
426,025
625,543,344
Health
Care
Providers
&
Services
1.1%
a
Guardant
Health,
Inc.
..................................
United
States
173,066
8,682,721