2
a
a
Country
Shares
a
Value
a
Common
Stocks
94.2%
Biotechnology
75.9%
a
89bio,
Inc.
...........................................
United
States
180,800
$
5,492,704
a
ACADIA
Pharmaceuticals,
Inc.
...........................
United
States
294,600
12,246,522
a
Acceleron
Pharma,
Inc.
.................................
United
States
136,900
13,576,373
a,b
ADMA
Biologics,
Inc.
...................................
United
States
437,264
1,561,032
a,b
Akouos
,
Inc.
.........................................
United
States
157,600
3,081,080
a
Alector
,
Inc.
..........................................
United
States
331,600
5,196,172
a
Alexion
Pharmaceuticals,
Inc.
............................
United
States
260,000
26,647,400
a
Alnylam
Pharmaceuticals,
Inc.
............................
United
States
52,300
7,623,248
a
ALX
Oncology
Holdings,
Inc.
.............................
United
States
86,100
2,815,470
Amgen,
Inc.
.........................................
United
States
318,700
77,976,329
a,b
Applied
Molecular
Transport,
Inc.
.........................
United
States
59,800
1,329,354
a
Applied
Therapeutics,
Inc.
...............................
United
States
154,857
3,995,311
a
Arcus
Biosciences,
Inc.
.................................
United
States
311,000
6,120,480
a
Argenx
SE,
ADR
......................................
Netherlands
164,525
37,862,138
a
Ascendis
Pharma
A/S,
ADR
.............................
Denmark
211,600
29,118,276
a
Assembly
Biosciences,
Inc.
..............................
United
States
256,700
5,698,740
a
Autolus
Therapeutics
plc,
ADR
...........................
United
Kingdom
232,430
3,068,076
a
Avidity
Biosciences,
Inc.
................................
United
States
128,900
3,633,691
a
Biogen,
Inc.
.........................................
United
States
189,175
51,964,481
a
BioMarin
Pharmaceutical,
Inc.
............................
United
States
142,456
17,067,653
a
Black
Diamond
Therapeutics,
Inc.
.........................
United
States
127,800
3,555,396
a
Bluebird
Bio,
Inc.
......................................
United
States
30,900
1,875,630
a
Blueprint
Medicines
Corp.
...............................
United
States
96,800
7,083,824
a,b
Bridgebio
Pharma,
Inc.
.................................
United
States
118,800
3,343,032
a
Constellation
Pharmaceuticals,
Inc.
........................
United
States
290,800
7,819,612
a
CRISPR
Therapeutics
AG
...............................
Switzerland
166,314
14,213,194
a
Deciphera
Pharmaceuticals,
Inc.
..........................
United
States
496,454
23,020,572
a
Fate
Therapeutics,
Inc.
.................................
United
States
490,193
15,328,335
a,b
Forte
Biosciences,
Inc.
.................................
United
States
414,264
7,808,876
Gilead
Sciences,
Inc.
..................................
United
States
803,200
55,846,496
a
Global
Blood
Therapeutics,
Inc.
...........................
United
States
295,200
19,920,096
a
Gossamer
Bio,
Inc.
....................................
United
States
439,100
5,234,072
a
Heron
Therapeutics,
Inc.
................................
United
States
1,739,677
28,339,338
a
Homology
Medicines,
Inc.
...............................
United
States
138,400
1,819,960
a
Immunomedics
,
Inc.
...................................
United
States
1,204,700
50,874,481
a
Insmed
,
Inc.
.........................................
United
States
871,500
22,763,580
a,c,d
Intarcia
Therapeutics,
Inc.,
DD
...........................
United
States
80,195
—
a
Ionis
Pharmaceuticals,
Inc.
..............................
United
States
102,400
5,894,144
a
Iovance
Biotherapeutics
,
Inc.
.............................
United
States
1,418,701
41,241,638
a
iTeos
Therapeutics,
Inc.
................................
United
States
36,700
722,256
a
KalVista
Pharmaceuticals,
Inc.
...........................
United
States
99,100
974,153
a
Kezar
Life
Sciences,
Inc.
................................
United
States
853,550
3,730,014
a
Legend
Biotech
Corp.,
ADR
.............................
United
States
66,600
2,346,984
a,b
LogicBio
Therapeutics,
Inc.
..............................
United
States
280,700
2,200,688
a
Mirati
Therapeutics,
Inc.
................................
United
States
146,151
17,729,578
a
Neurocrine
Biosciences,
Inc.
.............................
United
States
163,800
19,714,968
a
Nkarta
,
Inc.
..........................................
United
States
238,955
6,153,091
a
Novavax
,
Inc.
........................................
United
States
382,500
54,735,750
a
Pfenex
,
Inc.
.........................................
United
States
366,013
2,595,032
a,e
Precision
BioSciences
,
Inc.,
144A
.........................
United
States
73,892
469,953
a
Precision
BioSciences
,
Inc.
..............................
United
States
377,397
2,400,245
a
Principia
Biopharma,
Inc.
...............................
United
States
64,400
5,383,840
a
PTC
Therapeutics,
Inc.
.................................
United
States
752,100
34,844,793
a
Regeneron
Pharmaceuticals,
Inc.
.........................
United
States
146,709
92,730,358
a,b
Repare
Therapeutics,
Inc.
...............................
Canada
38,100
909,066
a
REVOLUTION
Medicines,
Inc.
...........................
United
States
148,900
3,591,468
a
Rocket
Pharmaceuticals,
Inc.
............................
United
States
433,371
10,197,220
a
Sage
Therapeutics,
Inc.
................................
United
States
101,070
4,605,760