CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (Unaudited) - USD ($) $ in Millions	3 Months Ended
	Mar. 31, 2024	Mar. 31, 2023
Cash flows from operating activities:
Net income	$ 722.0	$ 817.8
Adjustments to reconcile net income to net cash provided by operating activities:
Depreciation and amortization	114.1	99.5
Stock-based compensation expense	230.1	238.7
Losses on marketable and other securities, net	196.1	166.6
Other non-cash items, net	0.1	20.6
Deferred income taxes	(190.4)	(216.5)
Changes in assets and liabilities:
Decrease in accounts receivable	446.8	210.1
Increase in inventories	(155.8)	(46.8)
Increase in prepaid expenses and other assets	(77.9)	(5.5)
Increase (decrease) in deferred revenue	116.9	(35.9)
Increase in accounts payable, accrued expenses, and other liabilities	110.5	119.0
Total adjustments	790.5	549.8
Net cash provided by operating activities	1,512.5	1,367.6
Cash flows from investing activities:
Purchases of marketable and other securities	(5,657.5)	(1,749.4)
Sales or maturities of marketable and other securities	4,132.2	1,792.8
Capital expenditures	(133.9)	(178.2)
Payments for Libtayo intangible asset	(27.9)	(100.9)
Net cash used in investing activities	(1,687.1)	(235.7)
Cash flows from financing activities:
Proceeds from issuance of Common Stock	682.1	485.2
Payments in connection with Common Stock tendered for employee tax obligations	(343.7)	(97.0)
Repurchases of Common Stock	(291.3)	(710.7)
Net cash provided by (used in) financing activities	47.1	(322.5)
Effect of exchange rate changes on cash, cash equivalents, and restricted cash	(0.5)	0.0
Net (decrease) increase in cash, cash equivalents, and restricted cash	(128.0)	809.4
Cash, cash equivalents, and restricted cash at beginning of period	2,737.8	3,119.4
Cash, cash equivalents, and restricted cash at end of period	$ 2,609.8	$ 3,928.8