CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE INCOME - USD ($) shares in Millions, $ in Millions	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2021
Revenues:
Revenue from contract with customer	$ 13,117.2	$ 12,172.9	$ 16,071.7
Expenses:
Research and development	4,439.0	3,592.5	2,860.1
Acquired in-process research and development	186.1	255.1	48.0
Selling, general, and administrative	2,631.3	2,115.9	1,824.9
Other operating (income) expense, net	(2.1)	(89.9)	(45.6)
Total expenses	9,070.1	7,434.0	7,124.9
Income from operations	4,047.1	4,738.9	8,946.8
Other income (expense):
Other income (expense), net	225.2	179.3	436.3
Interest expense	(73.0)	(59.4)	(57.3)
Total other income (expense)	152.2	119.9	379.0
Income before income taxes	4,199.3	4,858.8	9,325.8
Income tax expense	245.7	520.4	1,250.5
Net income	$ 3,953.6	$ 4,338.4	$ 8,075.3
Net income per share - basic (in dollars per share)	$ 37.05	$ 40.51	$ 76.40
Net income per share - diluted (in dollars per share)	$ 34.77	$ 38.22	$ 71.97
Weighted average shares outstanding - basic (in shares)	106.7	107.1	105.7
Weighted average shares outstanding - diluted (in shares)	113.7	113.5	112.2
Statements of Comprehensive Income
Net income	$ 3,953.6	$ 4,338.4	$ 8,075.3
Other comprehensive income (loss), net of tax:
Unrealized gain (loss) on debt securities	158.2	(213.6)	(56.4)
Loss on foreign currency translation	(0.3)	0.0	0.0
Unrealized gain on cash flow hedges	0.0	1.0	0.9
Comprehensive income	4,111.5	4,125.8	8,019.8
Net product sales
Revenues:
Revenue from contract with customer	7,078.0	6,893.7	12,117.2
Expenses:
Cost of goods sold and of collaboration and contract manufacturing	932.1	800.0	1,773.1
Collaboration revenue
Revenues:
Revenue from contract with customer	5,503.1	4,914.1	3,673.3
Other revenue
Revenues:
Revenue from contract with customer	536.1	365.1	281.2
Cost of collaboration and contract manufacturing
Expenses:
Cost of goods sold and of collaboration and contract manufacturing	$ 883.7	$ 760.4	$ 664.4