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Property, Plant, and Equipment
 12 Months Ended
Dec. 31, 2023
Property, Plant and Equipment [Abstract]  
Property, Plant, and Equipment Property, Plant, and Equipment
Property, plant, and equipment, net consists of the following:
As of December 31,
(In millions)20232022
Building and improvements$2,423.1 $2,270.0 
Leasehold improvements133.9 114.3 
Laboratory equipment1,384.5 1,315.3 
Computer equipment and software389.7 337.4 
Furniture, office equipment, and other
165.9 150.2 
Land283.1 264.5 
Construction in progress1,345.0 980.5 
6,125.2 5,432.2 
Accumulated depreciation and amortization
(1,978.8)(1,669.2)
$4,146.4 $3,763.0 
Property, plant, and equipment in the table above includes leased property under the Company's finance lease at its Tarrytown, New York facility. See Note 11.
Depreciation and amortization expense on property, plant, and equipment was $328.8 million, $303.9 million, and $281.1 million for the years ended December 31, 2023, 2022, and 2021, respectively.
As of December 31, 2023 and 2022, $3.375 billion and $2.960 billion, respectively, of the Company's net property, plant, and equipment was located in the United States and $771.4 million and $803.0 million, respectively, was located outside the United States (primarily in Ireland).