CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE INCOME (Unaudited) - USD ($) shares in Millions, $ in Millions	3 Months Ended		9 Months Ended
	Sep. 30, 2023	Sep. 30, 2022	Sep. 30, 2023	Sep. 30, 2022
Revenues:
Revenues	$ 3,362.7	$ 2,936.2	$ 9,682.9	$ 8,758.5
Expenses:
Research and development	1,075.3	911.3	3,261.8	2,549.4
Acquired in-process research and development	100.0	0.0	156.1	225.1
Selling, general, and administrative	640.5	529.1	1,893.6	1,455.4
Other operating (income) expense, net	(0.5)	(45.7)	(1.6)	(83.3)
Total Expenses	2,251.7	1,712.5	6,608.7	5,166.4
Income from operations	1,111.0	1,223.7	3,074.2	3,592.1
Other income (expense):
Other income (expense), net	17.6	301.4	32.2	(16.0)
Interest expense	(17.8)	(15.3)	(54.7)	(42.0)
Total other income (expense)	(0.2)	286.1	(22.5)	(58.0)
Income before income taxes	1,110.8	1,509.8	3,051.7	3,534.1
Income tax expense	103.0	194.1	257.7	392.8
Net income	$ 1,007.8	$ 1,315.7	$ 2,794.0	$ 3,141.3
Net income per share - basic (in dollars per share)	$ 9.48	$ 12.31	$ 26.16	$ 29.30
Net income per share - diluted (in dollars per share)	$ 8.89	$ 11.66	$ 24.57	$ 27.73
Weighted average shares outstanding - basic (in shares)	106.3	106.9	106.8	107.2
Weighted average shares outstanding - diluted (in shares)	113.4	112.8	113.7	113.3
Statements of Comprehensive Income
Net income	$ 1,007.8	$ 1,315.7	$ 2,794.0	$ 3,141.3
Other comprehensive income (loss), net of tax:
Unrealized gain (loss) on debt securities	21.3	(51.3)	62.8	(249.9)
Loss on foreign currency translation	(0.4)	0.0	(0.8)	0.0
Unrealized gain on cash flow hedges	0.0	0.0	0.0	1.0
Comprehensive income	1,028.7	1,264.4	2,856.0	2,892.4
Net product sales
Revenues:
Revenues	1,786.1	1,801.4	5,226.2	5,194.4
Expenses:
Cost of goods, collaboration and contract manufacturing	224.5	141.3	625.3	497.8
Collaboration revenue
Revenues:
Revenues	1,438.3	1,050.6	4,133.1	3,326.7
Other revenue
Revenues:
Revenues	138.3	84.2	323.6	237.4
Cost of collaboration and contract manufacturing
Expenses:
Cost of goods, collaboration and contract manufacturing	$ 211.9	$ 176.5	$ 673.5	$ 522.0