CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE INCOME (Unaudited) - USD ($) shares in Millions, $ in Millions	3 Months Ended		6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022
Revenues:
Revenues	$ 3,158.1	$ 2,857.2	$ 6,320.2	$ 5,822.3
Expenses:
Research and development	1,085.3	794.3	2,186.5	1,638.1
Acquired in-process research and development	0.0	197.0	56.1	225.1
Selling, general, and administrative	652.0	476.3	1,253.1	926.3
Other operating (income) expense, net	(0.6)	(17.4)	(1.1)	(37.6)
Total Expenses	2,141.6	1,747.3	4,357.0	3,453.9
Income from operations	1,016.5	1,109.9	1,963.2	2,368.4
Other income (expense):
Other income (expense), net	85.3	(133.6)	14.6	(317.4)
Interest expense	(18.9)	(13.1)	(36.9)	(26.7)
Total other income (expense)	66.4	(146.7)	(22.3)	(344.1)
Income before income taxes	1,082.9	963.2	1,940.9	2,024.3
Income tax expense	114.5	111.1	154.7	198.7
Net income	$ 968.4	$ 852.1	$ 1,786.2	$ 1,825.6
Net income per share - basic (in dollars per share)	$ 9.05	$ 7.90	$ 16.69	$ 17.01
Net income per share - diluted (in dollars per share)	$ 8.50	$ 7.47	$ 15.68	$ 16.07
Weighted average shares outstanding - basic (in shares)	107.0	107.9	107.0	107.3
Weighted average shares outstanding - diluted (in shares)	113.9	114.0	113.9	113.6
Statements of Comprehensive Income
Net income	$ 968.4	$ 852.1	$ 1,786.2	$ 1,825.6
Other comprehensive income (loss), net of tax:
Unrealized (loss) gain on debt securities	(15.7)	(53.7)	41.5	(198.6)
Loss on foreign currency translation	(0.4)	0.0	(0.4)	0.0
Unrealized gain on cash flow hedges	0.0	0.0	0.0	1.0
Comprehensive income	952.3	798.4	1,827.3	1,628.0
Net product sales
Revenues:
Revenues	1,772.1	1,754.4	3,440.1	3,393.0
Expenses:
Cost of goods, collaboration and contract manufacturing	192.4	149.2	400.8	356.5
Collaboration revenue
Revenues:
Revenues	1,316.7	1,043.6	2,694.8	2,276.1
Other revenue
Revenues:
Revenues	69.3	59.2	185.3	153.2
Cost of collaboration and contract manufacturing
Expenses:
Cost of goods, collaboration and contract manufacturing	$ 212.5	$ 147.9	$ 461.6	$ 345.5