CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE INCOME (Unaudited) - USD ($) shares in Millions, $ in Millions	3 Months Ended
	Mar. 31, 2023	Mar. 31, 2022
Revenues:
Revenues	$ 3,162.1	$ 2,965.1
Expenses:
Research and development	1,101.2	843.8
Acquired in-process research and development	56.1	28.1
Selling, general, and administrative	601.1	450.0
Other operating (income) expense, net	(0.5)	(20.2)
Total Expenses	2,215.4	1,706.6
Income from operations	946.7	1,258.5
Other income (expense):
Other (expense) income, net	(70.7)	(183.8)
Interest expense	(18.0)	(13.6)
Total other income (expense)	(88.7)	(197.4)
Income before income taxes	858.0	1,061.1
Income tax expense	40.2	87.6
Net income	$ 817.8	$ 973.5
Net income per share - basic (in dollars per share)	$ 7.64	$ 9.12
Net income per share - diluted (in dollars per share)	$ 7.17	$ 8.61
Weighted average shares outstanding - basic (in shares)	107.1	106.8
Weighted average shares outstanding - diluted (in shares)	114.0	113.1
Statements of Comprehensive Income
Net income	$ 817.8	$ 973.5
Other comprehensive income (loss), net of tax:
Unrealized gain (loss) on debt securities	57.2	(144.9)
Unrealized gain on cash flow hedges	0.0	1.0
Comprehensive income	875.0	829.6
Net product sales
Revenues:
Revenues	1,668.0	1,638.6
Expenses:
Cost of goods, collaboration and contract manufacturing	208.4	207.3
Collaboration revenue
Revenues:
Revenues	1,378.1	1,232.5
Other revenue
Revenues:
Revenues	116.0	94.0
Cost of collaboration and contract manufacturing
Expenses:
Cost of goods, collaboration and contract manufacturing	$ 249.1	$ 197.6