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Stockholders' Equity - Narrative (Details)
1 Months Ended 12 Months Ended 14 Months Ended
May 31, 2020
USD ($)
shares
Dec. 31, 2022
USD ($)
vote
$ / shares
shares
Dec. 31, 2020
USD ($)
Dec. 31, 2020
USD ($)
Jan. 31, 2023
USD ($)
Dec. 31, 2021
$ / shares
shares
Nov. 30, 2021
USD ($)
Jan. 31, 2021
USD ($)
Nov. 30, 2019
USD ($)
Class of Stock [Line Items]                  
Preferred Stock, shares authorized (in shares) | shares   30,000,000       30,000,000.0      
Sanofi                  
Class of Stock [Line Items]                  
Cost of stock repurchased $ 5,000,000,000                
Number of shares sold (in shares) | shares 13,014,646                
Treasury stock, shares acquired (in shares) | shares 9,806,805                
Common Stock, shares outstanding (in shares) | shares 400,000                
Libtayo Development and Dupilumab/Itepekimab Eligible Investments                  
Class of Stock [Line Items]                  
Cost of stock repurchased     $ 135,000,000            
Bayer                  
Class of Stock [Line Items]                  
Maximum percentage of outstanding shares that may be acquired, under 'standstill' provisions   20.00%              
Teva                  
Class of Stock [Line Items]                  
Maximum percentage of outstanding shares that may be acquired, under 'standstill' provisions   5.00%              
January 2021 Share Repurchase Program                  
Class of Stock [Line Items]                  
Stock repurchase program, authorized amount               $ 1,500,000,000  
November 2021 Share Repurchase Program                  
Class of Stock [Line Items]                  
Stock repurchase program, authorized amount             $ 3,000,000,000    
Remaining authorized repurchase amount   $ 745,200,000              
2019 Share Repurchase Program                  
Class of Stock [Line Items]                  
Stock repurchase program, authorized amount                 $ 1,000,000,000
Cost of stock repurchased       $ 1,000,000,000          
Share Repurchase Program, January 2023 | Subsequent Event                  
Class of Stock [Line Items]                  
Stock repurchase program, authorized amount         $ 3,000,000,000        
Class A Stock                  
Class of Stock [Line Items]                  
Common Stock, shares authorized (in shares) | shares   40,000,000       40,000,000.0      
Common Stock, par value (in dollars per share) | $ / shares   $ 0.001       $ 0.001      
Number of votes per share | vote   10              
Common Stock, shares outstanding (in shares) | shares   1,800,000       1,800,000      
Common Stock                  
Class of Stock [Line Items]                  
Common Stock, shares authorized (in shares) | shares   320,000,000       320,000,000.0      
Common Stock, par value (in dollars per share) | $ / shares   $ 0.001       $ 0.001      
Number of votes per share | vote   1