Property, Plant, and Equipment

12 Months Ended

Dec. 31, 2022

Property, Plant and Equipment [Abstract]

Property, Plant and Equipment

Property, Plant, and Equipment

Property, plant, and equipment consists of the following:

	As of December 31,
(In millions)	2022		2021
Land	$	264.5	$	248.0
Building and improvements	2,270.0		2,088.5
Leasehold improvements	114.3		113.9
Construction in progress	980.5		767.7
Laboratory equipment	1,315.3		1,225.5
Computer equipment and software	337.4		291.5
Furniture, office equipment, and other	150.2		145.2
	5,432.2		4,880.3
Less, accumulated depreciation and amortization	(1,669.2)		(1,398.1)
	$	3,763.0	$	3,482.2

Property, plant, and equipment in the table above includes leased property under the Company's finance lease at its Tarrytown, New York facility. See Note 11.

Depreciation and amortization expense on property, plant, and equipment was $303.9 million, $281.1 million, and $230.8 million for the years ended December 31, 2022, 2021, and 2020, respectively.

As of December 31, 2022 and 2021, $2.960 billion and $2.684 billion, respectively, of the Company's net property, plant, and equipment was located in the United States and $803.0 million and $797.8 million, respectively, was located outside the United States (primarily in Ireland).