CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (Unaudited) - USD ($) $ in Millions	9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021
Cash flows from operating activities:
Net income	$ 3,141.3	$ 5,846.3
Adjustments to reconcile net income to net cash provided by operating activities:
Depreciation and amortization	241.3	211.7
Stock-based compensation expense	493.0	413.3
Losses (gains) on marketable and other securities, net	117.4	(524.6)
Other non-cash items, net	199.0	264.4
Deferred taxes	(466.7)	58.8
Acquired in-process research and development in connection with asset acquisition	195.0	0.0
Changes in assets and liabilities:
Decrease (increase) in accounts receivable	488.2	(1,342.9)
Increase in inventories	(552.2)	(330.6)
Increase in prepaid expenses and other assets	(167.3)	(316.8)
Increase (decrease) in deferred revenue	92.0	(71.2)
(Decrease) increase in accounts payable, accrued expenses, and other liabilities	(486.0)	500.4
Total adjustments	153.7	(1,137.5)
Net cash provided by operating activities	3,295.0	4,708.8
Cash flows from investing activities:
Purchases of marketable and other securities	(4,345.0)	(4,872.3)
Sales or maturities of marketable and other securities	4,013.1	1,897.3
Capital expenditures	(437.9)	(397.0)
Payments for Libtayo intangible asset	(926.8)	0.0
Asset acquisition, net of cash acquired	(230.3)	0.0
Net cash used in investing activities	(1,926.9)	(3,372.0)
Cash flows from financing activities:
Proceeds from issuance of Common Stock	1,146.9	1,129.6
Payments in connection with Common Stock tendered for employee tax obligations	(256.6)	(450.3)
Repurchases of Common Stock	(1,651.7)	(778.5)
Net cash used in financing activities	(761.4)	(99.2)
Net increase in cash, cash equivalents, and restricted cash	606.7	1,237.6
Cash, cash equivalents, and restricted cash at beginning of period	2,898.1	2,207.3
Cash, cash equivalents, and restricted cash at end of period	$ 3,504.8	$ 3,444.9