CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE INCOME (Unaudited) - USD ($) shares in Millions, $ in Millions	3 Months Ended		9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021
Revenues:
Revenues	$ 2,936.2	$ 3,452.8	$ 8,758.5	$ 11,120.0
Expenses:
Research and development	911.3	665.4	2,549.4	2,122.5
Acquired in-process research and development	0.0	0.0	225.1	0.0
Selling, general, and administrative	529.1	445.0	1,455.4	1,265.3
Other operating (income) expense, net	(45.7)	42.0	(83.3)	(29.8)
Costs and expenses, total	1,712.5	1,605.6	5,166.4	4,812.9
Income from operations	1,223.7	1,847.2	3,592.1	6,307.1
Other income (expense):
Other income (expense), net	301.4	(16.4)	(16.0)	558.5
Interest expense	(15.3)	(14.2)	(42.0)	(43.2)
Total other income (expense)	286.1	(30.6)	(58.0)	515.3
Income before income taxes	1,509.8	1,816.6	3,534.1	6,822.4
Income tax expense	194.1	184.4	392.8	976.1
Net income	$ 1,315.7	$ 1,632.2	$ 3,141.3	$ 5,846.3
Net income per share - basic (in dollars per share)	$ 12.31	$ 15.37	$ 29.30	$ 55.42
Net income per share - diluted (in dollars per share)	$ 11.66	$ 14.33	$ 27.73	$ 52.29
Weighted average shares outstanding - basic (in shares)	106.9	106.2	107.2	105.5
Weighted average shares outstanding - diluted (in shares)	112.8	113.9	113.3	111.8
Statements of Comprehensive Income
Net income	$ 1,315.7	$ 1,632.2	$ 3,141.3	$ 5,846.3
Other comprehensive income (loss), net of tax:
Unrealized loss on debt securities	(51.3)	(6.4)	(249.9)	(20.5)
Unrealized gain on cash flow hedges	0.0	0.2	1.0	0.7
Comprehensive income	1,264.4	1,626.0	2,892.4	5,826.5
Net product sales
Revenues:
Revenues	1,801.4	2,279.9	5,194.4	8,142.0
Expenses:
Cost of goods, collaboration and contract manufacturing	141.3	238.8	497.8	961.4
Collaboration revenue
Revenues:
Revenues	1,050.6	1,073.9	3,326.7	2,783.0
Other revenue
Revenues:
Revenues	84.2	99.0	237.4	195.0
Cost of collaboration and contract manufacturing
Expenses:
Cost of goods, collaboration and contract manufacturing	$ 176.5	$ 214.4	$ 522.0	$ 493.5