CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (Unaudited) - USD ($) $ in Millions	6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021
Cash flows from operating activities:
Net income	$ 1,825.6	$ 4,214.1
Adjustments to reconcile net income to net cash provided by operating activities:
Depreciation and amortization	148.7	138.5
Stock-based compensation expense	326.7	276.4
Losses (gains) on marketable and other securities, net	370.9	(553.9)
Other non-cash items, net	138.3	192.6
Deferred taxes	(381.0)	51.8
Acquired in-process research and development in connection with asset acquisition	195.0	0.0
Changes in assets and liabilities:
Decrease (increase) in accounts receivable	875.1	(2,883.9)
Increase in inventories	(328.7)	(221.5)
Increase in prepaid expenses and other assets	(288.5)	(277.8)
Increase (decrease) in deferred revenue	109.7	(64.8)
(Decrease) increase in accounts payable, accrued expenses, and other liabilities	(325.7)	423.7
Total adjustments	840.5	(2,918.9)
Net cash provided by operating activities	2,666.1	1,295.2
Cash flows from investing activities:
Purchases of marketable and other securities	(3,774.9)	(1,886.5)
Sales or maturities of marketable and other securities	2,181.4	1,217.1
Capital expenditures	(295.4)	(263.8)
Asset acquisition, net of cash acquired	(230.3)	0.0
Net cash used in investing activities	(2,119.2)	(933.2)
Cash flows from financing activities:
Proceeds from issuance of Common Stock	828.4	308.2
Payments in connection with Common Stock tendered for employee tax obligations	(147.7)	(180.7)
Repurchases of Common Stock	(717.1)	(612.1)
Net cash used in financing activities	(36.4)	(484.6)
Net increase (decrease) in cash, cash equivalents, and restricted cash	510.5	(122.6)
Cash, cash equivalents, and restricted cash at beginning of period	2,898.1	2,207.3
Cash, cash equivalents, and restricted cash at end of period	$ 3,408.6	$ 2,084.7