Collaboration, License, and Other Agreements - Amounts Recognized in Statement of Operations with Roche (Details) - USD ($) $ in Millions	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Disaggregation of Revenue [Line Items]
Revenues	$ 2,857.2	$ 5,138.5	$ 5,822.3	$ 7,667.2
Ronapreve | Roche Collaboration Agreement | Collaboration revenue
Disaggregation of Revenue [Line Items]
Revenues	$ 8.2	167.9	$ 224.5	234.7
Reimbursement of research and development expenses | Roche Collaboration Agreement | Research and development expense
Disaggregation of Revenue [Line Items]
Revenues		$ 41.0		$ 127.8