CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE INCOME (Unaudited) - USD ($) shares in Millions, $ in Millions	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Revenues:
Revenues	$ 2,857.2	$ 5,138.5	$ 5,822.3	$ 7,667.2
Expenses:
Research and development	794.3	714.2	1,638.1	1,457.1
Acquired in-process research and development	197.0	0.0	225.1	0.0
Selling, general, and administrative	476.3	414.7	926.3	820.3
Other operating (income) expense, net	(17.4)	(31.3)	(37.6)	(71.8)
Costs and expenses, total	1,747.3	1,791.3	3,453.9	3,207.3
Income from operations	1,109.9	3,347.2	2,368.4	4,459.9
Other income (expense):
Other (expense) income, net	(133.6)	420.0	(317.4)	574.9
Interest expense	(13.1)	(14.4)	(26.7)	(29.0)
Total other income (expense)	(146.7)	405.6	(344.1)	545.9
Income before income taxes	963.2	3,752.8	2,024.3	5,005.8
Income tax expense	111.1	653.9	198.7	791.7
Net income	$ 852.1	$ 3,098.9	$ 1,825.6	$ 4,214.1
Net income per share - basic (in dollars per share)	$ 7.90	$ 29.51	$ 17.01	$ 40.06
Net income per share - diluted (in dollars per share)	$ 7.47	$ 27.97	$ 16.07	$ 38.07
Weighted average shares outstanding - basic (in shares)	107.9	105.0	107.3	105.2
Weighted average shares outstanding - diluted (in shares)	114.0	110.8	113.6	110.7
Statements of Comprehensive Income
Net income	$ 852.1	$ 3,098.9	$ 1,825.6	$ 4,214.1
Other comprehensive income (loss), net of tax:
Unrealized loss on debt securities	(53.7)	(0.8)	(198.6)	(14.1)
Unrealized gain on cash flow hedges	0.0	0.3	1.0	0.5
Comprehensive income	798.4	3,098.4	1,628.0	4,200.5
Net product sales
Revenues:
Revenues	1,754.4	4,137.8	3,393.0	5,862.1
Expenses:
Cost of goods, collaboration and contract manufacturing	149.2	539.4	356.5	722.6
Collaboration revenue
Revenues:
Revenues	1,043.6	954.7	2,276.1	1,709.1
Other revenue
Revenues:
Revenues	59.2	46.0	153.2	96.0
Cost of collaboration and contract manufacturing
Expenses:
Cost of goods, collaboration and contract manufacturing	$ 147.9	$ 154.3	$ 345.5	$ 279.1