CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE INCOME (Unaudited) - USD ($) shares in Millions, $ in Millions	3 Months Ended		9 Months Ended
	Sep. 30, 2021	Sep. 30, 2020	Sep. 30, 2021	Sep. 30, 2020
Revenues:
Revenues	$ 3,452.8	$ 2,294.0	$ 11,120.0	$ 6,074.2
Expenses:
Research and development	665.4	684.6	2,122.5	1,990.5
Selling, general, and administrative	445.0	326.9	1,265.3	1,042.5
Other operating expense (income), net	42.0	(44.6)	(29.8)	(135.2)
Costs and expenses, total	1,605.6	1,240.9	4,812.9	3,664.6
Income from operations	1,847.2	1,053.1	6,307.1	2,409.6
Other income (expense):
Other (expense) income, net	(16.4)	(28.5)	558.5	218.3
Interest expense	(14.2)	(26.3)	(43.2)	(42.1)
Total other income (expense)	(30.6)	(54.8)	515.3	176.2
Income before income taxes	1,816.6	998.3	6,822.4	2,585.8
Income tax expense	184.4	156.2	976.1	221.8
Net income	$ 1,632.2	$ 842.1	$ 5,846.3	$ 2,364.0
Net income per share - basic (in dollars per share)	$ 15.37	$ 7.98	$ 55.42	$ 21.83
Net income per share - diluted (in dollars per share)	$ 14.33	$ 7.39	$ 52.29	$ 20.36
Weighted average shares outstanding - basic (in shares)	106.2	105.5	105.5	108.3
Weighted average shares outstanding - diluted (in shares)	113.9	113.9	111.8	116.1
Statements of Comprehensive Income
Net income	$ 1,632.2	$ 842.1	$ 5,846.3	$ 2,364.0
Other comprehensive income (loss), net of tax:
Unrealized (loss) gain on debt securities	(6.4)	(4.9)	(20.5)	10.9
Unrealized gain (loss) on cash flow hedges	0.2	0.2	0.7	(1.2)
Comprehensive income	1,626.0	837.4	5,826.5	2,373.7
Net product sales
Revenues:
Revenues	2,279.9	1,482.2	8,142.0	3,945.8
Expenses:
Cost of goods, collaboration and contract manufacturing	238.8	131.0	961.4	312.3
Collaboration revenue
Revenues:
Revenues	1,073.9	653.2	2,783.0	1,694.8
Other revenue
Revenues:
Revenues	99.0	158.6	195.0	433.6
Cost of collaboration and contract manufacturing
Expenses:
Cost of goods, collaboration and contract manufacturing	$ 214.4	$ 143.0	$ 493.5	$ 454.5