CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE INCOME (Unaudited) - USD ($) shares in Millions, $ in Millions	3 Months Ended		6 Months Ended
	Jun. 30, 2021	Jun. 30, 2020	Jun. 30, 2021	Jun. 30, 2020
Revenues:
Revenues	$ 5,138.5	$ 1,952.0	$ 7,667.2	$ 3,780.2
Expenses:
Research and development	714.2	722.0	1,457.1	1,305.9
Selling, general, and administrative	414.7	348.3	820.3	715.6
Other operating (income) expense, net	(31.3)	(50.2)	(71.8)	(90.6)
Costs and expenses, total	1,791.3	1,295.6	3,207.3	2,423.7
Income from operations	3,347.2	656.4	4,459.9	1,356.5
Other income (expense):
Other income (expense), net	420.0	272.2	574.9	246.8
Interest expense	(14.4)	(9.7)	(29.0)	(15.8)
Total other income (expense)	405.6	262.5	545.9	231.0
Income before income taxes	3,752.8	918.9	5,005.8	1,587.5
Income tax expense	653.9	21.6	791.7	65.6
Net income	$ 3,098.9	$ 897.3	$ 4,214.1	$ 1,521.9
Net income per share - basic (in dollars per share)	$ 29.51	$ 8.19	$ 40.06	$ 13.87
Net income per share - diluted (in dollars per share)	$ 27.97	$ 7.61	$ 38.07	$ 13.03
Weighted average shares outstanding - basic (in shares)	105.0	109.6	105.2	109.7
Weighted average shares outstanding - diluted (in shares)	110.8	117.9	110.7	116.8
Statements of Comprehensive Income
Net income	$ 3,098.9	$ 897.3	$ 4,214.1	$ 1,521.9
Other comprehensive income (loss), net of tax:
Unrealized (loss) gain on debt securities	(0.8)	44.6	(14.1)	15.8
Unrealized gain (loss) on cash flow hedges	0.3	0.0	0.5	(1.4)
Comprehensive income	3,098.4	941.9	4,200.5	1,536.3
Net product sales
Revenues:
Revenues	4,137.8	1,226.9	5,862.1	2,463.6
Expenses:
Cost of goods, collaboration and contract manufacturing	539.4	102.5	722.6	181.3
Collaboration revenue
Revenues:
Revenues	954.7	513.3	1,709.1	1,041.6
Other revenue
Revenues:
Revenues	46.0	211.8	96.0	275.0
Cost of collaboration and contract manufacturing
Expenses:
Cost of goods, collaboration and contract manufacturing	$ 154.3	$ 173.0	$ 279.1	$ 311.5