CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE INCOME (Unaudited) - USD ($) shares in Millions, $ in Millions	3 Months Ended
	Mar. 31, 2021	Mar. 31, 2020
Revenues:
Revenues	$ 2,528.7	$ 1,828.2
Expenses:
Research and development	742.9	583.9
Selling, general, and administrative	405.6	367.3
Other operating (income) expense, net	(40.5)	(40.4)
Costs and expenses, total	1,416.0	1,128.1
Income from operations	1,112.7	700.1
Other income (expense):
Other income (expense), net	154.9	(25.4)
Interest expense	(14.6)	(6.1)
Total other income (expense)	140.3	(31.5)
Income before income taxes	1,253.0	668.6
Income tax expense	137.8	44.0
Net income	$ 1,115.2	$ 624.6
Net income per share - basic (in dollars per share)	$ 10.58	$ 5.69
Net income per share - diluted (in dollars per share)	$ 10.09	$ 5.43
Weighted average shares outstanding - basic (in shares)	105.4	109.8
Weighted average shares outstanding - diluted (in shares)	110.5	115.1
Statements of Comprehensive Income
Net income	$ 1,115.2	$ 624.6
Other comprehensive income (loss), net of tax:
Unrealized loss on debt securities	(13.3)	(28.8)
Unrealized gain (loss) on cash flow hedges	0.2	(1.4)
Comprehensive income	1,102.1	594.4
Product
Revenues:
Revenues	1,724.3	1,236.7
Expenses:
Cost of goods sold	183.2	78.8
Collaboration revenue
Revenues:
Revenues	754.4	528.3
Product and service, other
Revenues:
Revenues	50.0	63.2
Cost of collaboration and contract manufacturing
Expenses:
Cost of goods sold	$ 124.8	$ 138.5