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Collaboration, License, and Other Agreements - Amounts Recognized in Statement of Operations with Teva (Details) - USD ($)
$ in Millions
12 Months Ended
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2018
Reimbursement of research and development expenses | Teva      
Disaggregation of Revenue [Line Items]      
Reduction of Research and development expense $ 109.4 $ 122.9 $ 129.5
Amounts recognized in connection with up-front and development milestone payments received      
Disaggregation of Revenue [Line Items]      
Other operating income $ 47.2 $ 82.2 $ 113.2