Property, Plant, and Equipment

12 Months Ended

Dec. 31, 2020

Property, Plant and Equipment [Abstract]

Property, Plant and Equipment

Property, Plant, and Equipment

Property, plant, and equipment consists of the following:

	As of December 31,
	2020		2019
Land	$	241.2	$	230.8
Building and improvements	1,891.1		1,683.4
Leasehold improvements	100.5		97.6
Construction in progress	724.5		644.8
Laboratory equipment	1,038.6		850.7
Computer equipment and software	226.3		183.7
Furniture, office equipment, and other	130.5		121.8
	4,352.7		3,812.8
Less, accumulated depreciation and amortization	(1,131.1)		(922.4)
	$	3,221.6	$	2,890.4

Property, plant, and equipment in the table above includes leased property under the Company's finance lease at its Tarrytown, New York facility. See Note 10.

Depreciation and amortization expense (including as it relates to the Company's finance lease) on property, plant, and equipment amounted to $230.8 million, $205.2 million, and $144.1 million for the years ended December 31, 2020, 2019, and 2018, respectively.

As of December 31, 2020 and 2019, $2.398 billion and $2.118 billion, respectively, of the Company's net property, plant, and equipment was located in the United States and $823.8 million and $772.8 million, respectively, was located in Europe (primarily in Ireland).