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Inventories
12 Months Ended
Dec. 31, 2020
Inventory Disclosure [Abstract]  
Inventories Inventories
Inventories consist of the following:
As of December 31,
20202019
Raw materials$459.4 $216.3 
Work-in-process904.6 727.7 
Finished goods121.7 70.6 
Deferred costs430.9 400.9 
$1,916.6 $1,415.5 
Deferred costs represent the costs of product manufactured and shipped to the Company's collaborators for which recognition of revenue has been deferred. For the years ended December 31, 2020, 2019, and 2018, Cost of goods sold included inventory write-downs and reserves of $39.2 million, $73.8 million, and $12.5 million, respectively.